TAT modified and lipid – PEI hybrid nanoparticles for co-delivery of docetaxel and pDNA

Dong, Shufang; Zhou, Xin; Yang, Jiying

doi:10.1016/j.biopha.2016.10.003

Cited by 29 publications

(15 citation statements)

References 41 publications

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“…Tissue engineering [48–51], gene therapy [52,53], cancer treatment [54,55], chemotherapy [56,57] and medical applications [58–60] are the applications of PEI.…”

Section: Applications Of Peimentioning

confidence: 99%

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Zakeri

Kouhbanani

Beheshtkhoo

et al. 2018

Nano Reviews & Experiments

227

150

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The meaning of gene therapy is the delivery of DNA or RNA to cells for the treatment or prevention of genetic disorders. The success rate of gene therapy depends on the progression and safe gene delivery system. The vectors available for gene therapy are divided into viral and non-viral systems. Viral vectors cause higher transmission efficiency and long gene expression, but they have major problems, such as immunogenicity, carcinogenicity, the inability to transfer large size genes and high costs. Non-viral gene transfer vectors have attracted more attention because they exhibit less toxicity and the ability to transfer large size genes. However, the clinical application of non-viral methods still faces some limitations, including low transmission efficiency and poor gene expression. In recent years, numerous methods and gene-carriers have been developed to improve gene transfer efficiency. The use of Polyethylenimine (PEI) based transfer of collaboration may create a new way of treating diseases and the combination of chemotherapy and gene therapy. The purpose of this paper is to introduce the PEI as an appropriate vector for the effective gene delivery.

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“…Tissue engineering [48–51], gene therapy [52,53], cancer treatment [54,55], chemotherapy [56,57] and medical applications [58–60] are the applications of PEI.…”

Section: Applications Of Peimentioning

confidence: 99%

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Zakeri

Kouhbanani

Beheshtkhoo

et al. 2018

Nano Reviews & Experiments

227

150

View full text Add to dashboard Cite

show abstract

“…They used this system for co-delivery of GRP78 siRNA and docetaxel (DTXL) in other to cure the PC-3 CRPC. In another study, Dong et al [142] tried to develop an effective co-delivery of docetaxel (DTX) and plasmid DNA (pDNA) for combination chemotherapy. They studied a cell-penetrating peptides (CPPs) modified lipid-PEI hybrid NPs (LPNs) and evaluated a modified RKKRRQRRR peptide (TAT), DTX, pDNA and LPNs (TAT-DTX/pDNA LPNs) in PC3 cancer cells (in vitro) and in a murine prostate cancer model (in vivo).…”

Section: Prostate Cancer Therapymentioning

confidence: 99%

In vivo gene delivery mediated by non-viral vectors for cancer therapy

Mohammadinejad

Dehshahri

Madamsetty

et al. 2020

Journal of Controlled Release

179

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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“…49 The major challenge to the design of these self-assembling nanoparticles was the co-encapsulation of the small molecule TKI with pDNA. Whilst several groups have developed multifunctional nanoparticles for combination therapy with small molecules and nucleic acids, [50][51][52][53][54] most of these approaches have focused on the co-delivery of siRNA, and many of the reported approaches are based on dendrimers, which have associated toxicities and result in the formation of heterogeneous mixtures. 55 In some cases where liposomal co-formulation of both nucleic acid and small molecule was attempted, aggregation of the liposome and leakage of the drug was seen.…”

Section: Design Of Lipopolyplex-based Theragnostic Nanoparticlesmentioning

confidence: 99%

Drug delivery, biodistribution and anti-EGFR activity: theragnostic nanoparticles for simultaneousin vivodelivery of tyrosine kinase inhibitors and kinase activity biosensors

et al. 2021

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TAT modified and lipid – PEI hybrid nanoparticles for co-delivery of docetaxel and pDNA

Cited by 29 publications

References 41 publications

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

Polyethylenimine-based nanocarriers in co-delivery of drug and gene: a developing horizon

In vivo gene delivery mediated by non-viral vectors for cancer therapy

Drug delivery, biodistribution and anti-EGFR activity: theragnostic nanoparticles for simultaneousin vivodelivery of tyrosine kinase inhibitors and kinase activity biosensors

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