Tasting Phenylthiocarbamide (PTC): A New Integrative Genetics Lab with an Old Flavor

Merritt, Robert B.; Bierwert, Lou Ann; Slatko, Barton E.; Weiner, Michael P.; Ingram, John R.; Sciarra, Kristianna; Weiner, Evan

doi:10.1662/0002-7685(2008)70[23:tppani]2.0.co;2

Cited by 12 publications

(25 citation statements)

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“…The following experiment, published by Robert B. Merritt (along with the editors and others), in The American Biology Teacher (1), is suitable for students in middle school, high school, or college. To suit any curriculum, elements can be added to emphasize molecular biology, genetics, population biology, and bioinformatic analysis.…”

Section: Tasting Ptc: a New Lab With An Old Flavormentioning

confidence: 99%

“…The only major resources needed are a thermal cycler, agarose gel electrophoresis, and detection ability. The complete protocol is accessible online without charge, and even includes an outline of how to make an inexpensive thermal cycler if a commercial model is not available (1). Alternatively, as with many experiments requiring equipment that schools may not have, this experiment provides the opportunity to bring the students into your laboratory to perform either the entire protocol or an individual PCR or electrophoresis step.…”

Section: Tasting Ptc: a New Lab With An Old Flavormentioning

confidence: 99%

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Education Outreach

Weiner¹,

Slatko

2009

BioTechniques

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Section: Tasting Ptc: a New Lab With An Old Flavormentioning

confidence: 99%

Section: Tasting Ptc: a New Lab With An Old Flavormentioning

confidence: 99%

Education Outreach

Weiner¹,

Slatko

2009

BioTechniques

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“…At the moment the obvious nature of inheritance of the sensitivity to PTC allows to use this trait as learning applications. One can show students in real life examples the mechanism of the PTC sensitivity inheritance and to solve genetic problems during the classes in genetics [14].…”

Section: Introductionmentioning

confidence: 99%

The population structure of Ukraine in relation to the phenylthiocarbamide sensitivity

Filiptsova

Timoshyna

Kobets

et al. 2015

Egyptian Journal of Medical Human Genetics

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Background: The taste sensitivity to phenylthiocarbamide (PTC) is one of the classical genetic markers in human studies. PTC is of great interest from the medical point of view since a number of associations of the taster status with human diseases have been found. The aim of our study was to evaluate the population structure of Ukraine in relation to PTC sensitivity.Methods: The study involved 533 people (78 males and 455 females) aged from 16 to 25 years. The PTC solution in the concentration of 0.13% was prepared according to the method of Harris and Kalmus. The participants of the study analyzed the taste of the filter paper impregnated with PTC. If the trial subjects tasted PTC as ''bitter'', ''very bitter'', ''bitterish'', the phenotype was defined as a taster. If the trial subject did not taste PTC (''no taste'', ''taste of paper''), he/she was referred to a non-taster.Results: The structure of the sample of the Ukrainian population studied in relation to the phenotypic and genotypic frequency associated with the phenylthiocarbamide sensitivity has been studied. It has been shown that in the population there are 22% of those who do not feel the taste of phenylthiocarbamide. Among males there are a few more non-tasters than among females, however, the differences are not significant. The frequency of the dominant and recessive allele of the phenylthiocarbamide sensitivity gene in the sample calculated on the basis of the Hardy-Weinberg equation is generally p T = 0.55 and q t = 0.45, respectively.Conclusions: Frequencies of alleles T and t obtained in the male and female population under research are very close to the frequencies of the same alleles in some populations of India. Data of this study supplement the currently available information in relation to the genetic structure of modern Ukrainian cities.

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“…O gene que condiciona o gosto amargo do PTC TAS2R38 está localizado no braço longo do cromossomo 7 (7q35-q36), e contém cerca de 1.002 pares de base (pb) em sua região codificadora (KIM et al, 2003;WOODING et al, 2004;MERRITT et al, 2008).…”

Section: Introductionunclassified

“…O gene TAS2R38, pertencente à família dos receptores para o amargo TAS2R, apresenta cinco formas alélicas, onde uma delas (t) condiciona a insensiUniversitas: Ciências da Saúde, Brasília, v. 7, n. 1, p. 45-56, 2009 O teste de sensibilidade à feniltiocarbamida (PTC) (KIM et al, 2003;MORAIS et al, 2007;MERRITT et al, 2008).…”

Section: Introductionunclassified

O teste de sensibilidade à feniltiocarbamida (PTC) usado como prática lúdica no ensino de genética

Freire¹,

Lima²

2009

Univ. Ci. Saúde

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Tasting Phenylthiocarbamide (PTC): A New Integrative Genetics Lab with an Old Flavor

Abstract: BioOne Complete (complete.BioOne.org) is a full-text database of 200 subscribed and open-access titles in the biological, ecological, and environmental sciences published by nonprofit societies, associations, museums, institutions, and presses.

Cited by 12 publications

References 7 publications

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The population structure of Ukraine in relation to the phenylthiocarbamide sensitivity

O teste de sensibilidade à feniltiocarbamida (PTC) usado como prática lúdica no ensino de genética

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