Taste Masking Using Hot‐Melt Extrusion

Douroumis, Dennis; Bonnefille, Marion; Aranyos, Attila

doi:10.1002/9780470711415.ch9

Cited by 10 publications

(11 citation statements)

References 31 publications

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“…In another study, Dhumal et al emphasized the importance of screw configuration in regards to extrusion processing, though once a suitable configuration was established, did not find it to be a significant factor in the scale-up of production [ 36 ]. Screw speed must also be increased with the feed rate, otherwise, the extruder will clog [ 41 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

et al. 2021

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The aim of the study was the manufacturing and scale-up of theophylline-nicotinamide (THL-NIC) pharmaceutical cocrystals processed by hot-melt extrusion (HME). The barrel temperature profile, feed rate and screw speed were found to be the critical processing parameters with a residence time of approximately 47 s for the scaled-up batches. Physicochemical characterization using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction of bulk and extruded materials revealed the formation of high purity cocrystals (98.6%). The quality of THL-NIC remained unchanged under accelerated stability conditions.

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Section: Resultsmentioning

confidence: 99%

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

et al. 2021

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“…Hot melt extrusion (HME) is used in FDM printing to produce filaments. Advantages of this method for taste masking over the previously mentioned ones include the applicability of the method for water-soluble drugs, a continuous process design that is easy to scale up, and potential offering of good drug stability in the matrix [ 14 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Mini Tablets for Pediatric Use

et al. 2021

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In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.

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“…However, the potential for HME applications in pharmaceutical research and development has not yet been fully realized, mainly owing to the complexity of HME design and the non-Newtonian behavior of the extruded materials (Thomas and Yang, 2009). This makes it somewhat difficult to predict the behavior of materials processed by HME using mathematical modeling (Douroumis, 2012). …”

Section: Introductionmentioning

confidence: 99%

“…Although the pharmaceutical literature strongly suggests that there is a definite need to investigate the influences of screw torque and degassing (Rauwendaal, 1998), pertinent studies relating to the impact of the degassing process on pharmaceutical applications are limited. Degassing is generally regarded in the pharmaceutical industry as merely an additional step in the manufacturing process (Douroumis, 2012). In the production of plastics and food, degassing has been intensely investigated and several studies have shown it to have a considerable influence on the properties of the final product (Kohlgrüber, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Generally, gases may arise from the air trapped during the feeding process, or from the processed materials (Repka et al, 2013). Materials extruded with either polymers or active pharmaceutical ingredients (API) can have air trapped in the pores or adherent to their surfaces (Douroumis, 2012). The entrapped molecules may affect other processing parameters as well as the quality of the product.…”

Section: Introductionmentioning

confidence: 99%

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Influence of degassing on hot-melt extrusion process

Alshahrani

Morott

Alshetaili

et al. 2015

European Journal of Pharmaceutical Sciences

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The present study aimed to evaluate the effect of degassing on an extrusion process, with respect to extrudate quality and drug release properties. Processed formulations were extruded with and without a degassing vent port at various locations along the barrel. All the experiments were performed under constant processing temperature, feeding rate, and screw speed. During the extrusion process, torque and pressure were monitored and recorded. The degassing process was beneficial when used over a conveying section after a mixing section. This is attributed to the large surface area available on the conveying elements, which minimizes the internal volume of the processed material, thereby facilitating the escape of entrapped gases. Degassing enhanced the homogeneity, physical appearance, and drug release properties of all the formulations. Furthermore, the degassing process also enhanced the cross-sectional uniformity of the extruded material, which is beneficial for visual monitoring during processing. Degassing considerably reduced the post-extrusion moisture content of Formula D3, which contains the highly hygroscopic polymer Kollidon® 17 PF, suggesting that the greatest influence of this process is on hygroscopic materials. The reduction in post-extrusion moisture content resulting from the inclusion of a degassing vent port, reduced fluctuations in the values of in-line monitoring parameters such as pressure and torque. Employing a degassing unit during hot-melt extrusion processing could help increase process efficacy and product quality.

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Taste Masking Using Hot‐Melt Extrusion

Cited by 10 publications

References 31 publications

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

3D Printing of Mini Tablets for Pediatric Use

Influence of degassing on hot-melt extrusion process

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