Taste masking of Etoricoxib by using ion-exchange resin

Patra, Sradhanjali; Samantaray, Rakesh; Pattnaik, Swapnajit; Barik, B. B.

doi:10.3109/10837450903322787

Cited by 19 publications

(9 citation statements)

References 3 publications

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“…The ion-exchange resin particles were dispersed in a drug ethanol solution with a mass ratio of 1:2 under magnetic stirring until equilibrium state. The influences of ethanol concentrations (40, 50, 60 and 75 %), pH 2.0, 3.0 and 4.2 of the solution, temperature (15,20,25 and 30 °C) on drug loading were investigated. The complexes were separated by filtration and washed with deionized water to remove unbound drug and other ions.…”

Section: Preparation and Optimization Of Drug-resin Complexesmentioning

confidence: 99%

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Development and evaluation of orally disintegrating tablets containing the mosapride resin complex

Wang

Shi

et al. 2018

Acta Pharmaceutica

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The purpose of this study was to prepare a mosapride citrate-resin (Amberlite® IRP 88) complex and orally fast-disintegrating tablets of the resin complex. The resinate complex of mosapride-Amberlite® IRP 88, mass ratio 2:1, was prepared in an ethanol-water solution. The effects of alcohol concentration, temperature, and pH of the solution on complex formation were evaluated. The complex physicochemical properties were characterized by differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Orally disintegrating tablets were prepared by direct compression and were optimized using the response surface method. Optimized orally fast-disintegrating tablets disintegrated within 18 s. The pH dependence of mosapride release from the tablet decreased drug dissolution in simulated saliva, whereas it promptly released in the pH 1.0 solution. The data reported herein clearly demonstrate that tablets containing the mosapride-Amberlite® IRP 88 complex for oral disintegration could be particularly useful for patients with swallowing difficulties.

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Section: Preparation and Optimization Of Drug-resin Complexesmentioning

confidence: 99%

“…These tablets disperse in the oral cavity, and then the active ingredient dissolves in saliva to be absorbed. For some drugs, disintegrating tablets may have higher bioavailability than the conventional formulation (15,16).…”

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confidence: 99%

Development and evaluation of orally disintegrating tablets containing the mosapride resin complex

Wang

Shi

et al. 2018

Acta Pharmaceutica

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“…The diffused disks of each sample are placed on the agar. Plates were then incubated at 37°C for 24hrs [23][24] .…”

Section: Screening Of Bacteriamentioning

confidence: 99%

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2017

IJPSR

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Pyrazoles and fused heterocyclic pyrazoles derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activity in the field of pharmaceutical science, agriculture etc. In the present study, new substituted pyrazoles were prepared by condensation of substituted primary amine and ethyl acetoacetate at 140 0 C to form analides as intermediate. These intermediates on further reaction with hydrazine hydrate using ethanol as solvent and converted into pyrazoles. The synthesized compounds were characterised by their physical properties, IR, NMR and elemental analysis techniques. The purity of the compounds and completion of reaction was tested by TLC Technique using ethyl acetate and petroleum ether as an eluent (6:4). The antimicrobial activity of synthesized pyrazoles was assessed by Disk diffusion method using gram positive and gram negative strains. The benzoyl and nitroso derivatives were also prepared to confirm the formation of new compounds. The derivative of these compounds also shows good antimicrobial activity. INTRODUCTION: The chemistry of heterocyclic compounds is one of the most complex and important stream of organic chemistry. Because of the diverse properties, easily accessible path and the wide range of biological activities, these are centre of attraction for organic chemist to synthesise various heterocyclic compounds 1-3. The literature survey reveals the importance of pyrazole derivatives as an intermediate in the medicinal chemistry 4-6. Pyrazoles and their substituted derivatives are interesting potential pharmaceuticals. They exhibit wide variety of biological and pharmaceutical activities. Therefore, they play important role in medicinal chemistry 7 .

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“…In the past, IRs were primarily used in the field of agriculture and for the purification of water (Mantell, 1951 ). Application of IRs as excipients in the field of medicine started when synthetic ion-exchange resins were used as taste masking and as stabilizing agents in oral dosage forms (Kankkunen et al, 2002 ; Bhise et al, 2008 ; Patra et al, 2010 ; The Dow Chemical Company ). Moreover, drug-IR complexes show modified release profiles when compared to the release of free drug (Halder & Sa, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery

et al. 2017

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The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFS free ) and DFS:Ion exchange resin complexes (DFS:IR) for immediate and sustained release profiles, respectively. Methods: Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFS free , or a combination of DFS free + DFS:IR loaded matrix films were prepared by melt-cast technology. DFS content was 20% w/w in these matrix films.In vitro transcorneal permeability from the film formulations were compared against DFS solution, using a side-by-side diffusion apparatus, over a 6 h period. Ocular disposition of DFS from the solution, films and corresponding suspensions were evaluated in conscious New Zealand albino rabbits, 4 h and 8 h post-topical administration. All in vivo studies were carried out as per the University of Mississippi IACUC approved protocol.Results: Complexation efficiency of DFS:IR was found to be 99% with a 1:1 ratio of DFS:IR. DFS release from DFS:IR suspension and the film were best-fit to a Higuchi model. In vitro transcorneal flux with the DFS free + DFS:IR (1:1) (1 + 1) was twice that of only DFS:IR (1:1) film. In vivo, DFS solution and DFS:IR (1:1) suspension formulations were not able to maintain therapeutic DFS levels in the aqueous humor (AH). Both DFS free and DFS free + DFS:IR (1:1) (3 + 1) loaded matrix films were able to achieve and maintain high DFS concentrations in the AH, but elimination of DFS from the ocular tissues was much faster with the DFS free formulation. Conclusion: DFS free + DFS:IR combination loaded matrix films were able to deliver and maintain therapeutic DFS concentrations in the anterior ocular chamber for up to 8 h. Thus, free drug/IR complex loaded matrix films could be a potential topical ocular delivery platform for achieving immediate and sustained release characteristics. KeywordsIon exchange resins, immediate release formulations, ocular drug delivery, diclofenac sodium and polymeric matrix films History

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Taste masking of Etoricoxib by using ion-exchange resin

Cited by 19 publications

References 3 publications

Development and evaluation of orally disintegrating tablets containing the mosapride resin complex

Development and evaluation of orally disintegrating tablets containing the mosapride resin complex

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Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery

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