Taste Mask, Design and Evaluation of an Oral Formulation Using Ion Exchange Resin as Drug Carrier

Bhise, Kiran; Shaikh, Shafi; Bora, Divyakumar

doi:10.1208/s12249-008-9056-6

Cited by 44 publications

(15 citation statements)

References 10 publications

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“…Taste of the formulation A2 was evaluated by time intensity method using a panel of human volunteers (21). For this purpose, nine healthy human volunteers were selected …”

Section: Evaluation Of Tastementioning

confidence: 99%

Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

Mali¹,

Dias²,

Ghorpade³

et al. 2017

Marmara Pharmaceutical Journal

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The aim of present investigation was to develop a taste masked fast dissolving sublingual strips of rizatriptan benzoate. The fast dissolving strips (FDS) were prepared by solvent casting method using polyox N-10 and polyethylene glycol 400 (PEG 400) as polymer and plasticizer respectively. The FDS were evaluated for pH, folding endurance, tensile strength, moisture absorption, disintegration time and in vitro dissolution. All formulations were free from bubble and exhibited smooth appearance. The pH of the films was acidic. It was observed that increase in the concentration of polyox N-10 increased the disintegration time but reduced the dissolution rate. The formulation A2 showed all the evaluation parameters within the acceptable range and was considered as optimized formulation. The optimized formulation was subjected to the taste masking and stability study. The results of taste masking study indicated an efficient masking of the bitter taste of drug by the flavouring agents in the film. The formulation A2 was found to be stable for three months with an insignificant change in the drug content and mean dissolution time (MDT). The compatibility study performed using ATR-FTIR and DSC analysis indicated absence of any unusual interaction between drug and excipients used in formulation. Thus, the FDS comprised of polyox N-10 and PEG 400 may be a better alternative to the other available fast dissolving systems for delivery of rizatriptan benzoate.

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“…Taste of the formulation A2 was evaluated by time intensity method using a panel of human volunteers (21). For this purpose, nine healthy human volunteers were selected …”

Section: Evaluation Of Tastementioning

confidence: 99%

Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

Mali¹,

Dias²,

Ghorpade³

et al. 2017

Marmara Pharmaceutical Journal

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“…The DRCs were evaluated for bulk density, tapped density, compressibility, angle of repose and Hausner's ratio [15] .…”

Section: Micromeriticsmentioning

confidence: 99%

Design, Optimization and Evaluation of Chewable Tablets of Clarithromycin using Ion Exchange Resins

Dasankoppa¹,

Sholapur²,

Swamy³

et al. 2016

pharmaceutical-sciences

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Fatima, et al.: Chewable Tablets with Ion Exchange ResinsIon exchange resins are water-insoluble, cross-linked polymers containing salt-forming groups in repeating positions on the polymer chain. Bitter cationic drugs get adsorbed on to weak cationic exchange resins of carboxylic acid functionality like Indion 204, Indion 234 and Tulsion 335 to forms non-bitter complexes. The present investigation aims at taste masking of the bitter clarithromycin using ion exchange resins, which forms complexes, inhibiting its release in saliva. The drug-resin complex loading process was optimized for the content of resin, activation, swelling time, stirring time, influence of pH and temperature for maximum drug loading and was subjected to differential scanning calorimetry to confirm the complex formation. These complexes were used to prepare chewable tablets and to evaluate the taste. Acid-activated resins comprising of Indion 204, Indion 234 and Tulsion 335 with drug:resin ratio of 1:2, stirred in solution of pH 7-8 at 70° for 6 h had a maximum drug loading and masked the bitter taste of clarithromycin. Differential scanning calorimetry of the drug-resin complex revealed that there was interaction leading to complex formation. The drug-resin complex was formulated into chewable tablet formulations (F1-F9) and evaluated. Various pre-and post-compression parameters were found to be within permissible limits. Formulations F3, F6 and F9 containing 1:2 ratios of drug-resin complex of Indion 204, Indion 234 and Tulsion 335 revealed maximum taste masking. This was further confirmed by treatment of taste evaluation scores of the volunteers by ANOVA, Dunnets multiple comparison test and Tukey's multiple comparison test. All the three optimized formulations had a significant difference of P<0.001 when compared to control F10. F6 formulation was widely accepted. Ion exchange complexation could efficiently mask the bitter taste of clarithromycin and achieve palatable taste suitable for paediatric use.

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“…The resin was o then dried in vacuum oven at 60 C till the moisture content came below 5% conrmed by Karl Fisher titration. The puried resin was stored in an air tight glass 16 vial .…”

Section: Purification and Activation Of Resinmentioning

confidence: 99%

Central Composite Designed Taste Masked Ion Exchange Resinates for Development of Azithromycin Dispersible Tablets

Kaushik¹,

Dureja²

2015

Journal of Pharmaceutical Research

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ABTRSACT Purpose:The purpose of the present investigation was to formulate taste masked dispersible tablets of azithromycin using complexation by ion exchange resin applying the central composite design. Methodology:The basic methodology behind the present work was the application of ion exchange resin complexation for masking the bitter taste of azithromycin. The central composite design (CCD) was applied to study the effect of two critical factors i.e. swelling time (X ) and stirring time (X ) on percent drug 1 2 complexed and cumulative percentage drug release. ANOVA was applied to percent drug complexed and cumulative percentage drug release to study the tting and the signicance of the model. The drug resinate was nally formulated into dispersible tablets by direct compression method. Findings:The drug resin ratio of 1:3 and pH 6 were found to have maximum drug loading onto the resin (Tulsion 335). The maximum drug release was found at high values of swelling and stirring time. The techniques of differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) clearly indicated the formation of drug resin complex. Further, the formulated tablets were found to be within the pharmacopoeial limits. Originality:The present work is a novel attempt to prepare optimized taste masked formulation of extremely bitter drug azithromycin to overcome the problem of swallowing conventional tablets in case of paediatric patients. Conclusion:The technique of ion exchange resin complexation was successfully applied to prepare the taste masked azithromycin dispersible tablets. Data revealed that the developed dispersible tablets showed better taste prole when compared with the marketed formulation and were found to be stable.

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Taste Mask, Design and Evaluation of an Oral Formulation Using Ion Exchange Resin as Drug Carrier

Cited by 44 publications

References 10 publications

Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

Design, Optimization and Evaluation of Chewable Tablets of Clarithromycin using Ion Exchange Resins

Central Composite Designed Taste Masked Ion Exchange Resinates for Development of Azithromycin Dispersible Tablets

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