Taste function in patients with Parkinson disease

Kim, Han Joon; Jeon, Beomseok; Lee, Jee Young; Cho, Yong Jin; Hong, Kyung Soon; Cho, Joong-Yang

doi:10.1007/s00415-010-5884-x

Cited by 35 publications

(30 citation statements)

References 19 publications

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“…Taste is a powerful determinant of food choices (Glanz, Basil, Maibach, Goldberg, & Snyder, 1998). Although PD patients may suffer from taste dysfunctions (Cecchini et al, 2014;Deeb et al, 2010;Kashihara, Hanaok, & Imamura, 2011;Kim et al, 2011;Shah et al, 2009;Sienkiewicz-Jarosz et al, 2005), to date no study has evaluated taste before and/or after DBS or correlated it with weight or food habits. Olfactory problems occur in 90% of early-stage PD patients, and can precede the onset of motor symptoms by years (Doty, 2012).…”

Section: Sensory Perception: Taste and Olfactionmentioning

confidence: 98%

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

2015

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Section: Sensory Perception: Taste and Olfactionmentioning

confidence: 98%

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

2015

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“…More recently, Moberg et al [13] noted that only 24 % of 56 PD patients could detect the bitter taste of phenylthiocarbamide (PTC), as compared to 75 % of 20 healthy controls. Kim et al [14] found a marginal decrease in identification performance of 15 women with PD relative to 14 female controls when the data were combined across sweet, sour, bitter and salty tastants. However, the effects were not significant when any one taste quality was assessed alone.…”

Section: Introductionmentioning

confidence: 98%

Taste function in early stage treated and untreated Parkinson’s disease

et al. 2014

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Since brain stem regions associated with early Parkinson's disease (PD) pathology encroach upon those involved in taste function, the ability to taste may be compromised in PD. However, studies on this point have been contradictory. We administered well-validated whole-mouth and regional taste tests that incorporated multiple concentrations of sucrose, citric acid, caffeine, and sodium chloride to 29 early stage PD patients and 29 age-, sex-, and race-matched controls. Electrogustometry was also performed on the anterior tongue. The PD cohort was tested both on and off dopamine-related medications in counterbalanced test sessions. While whole-mouth taste identification test scores for all stimuli were, on average, nominally lower for the PD patients than for the controls, a trend in the opposite direction was noted for the intensity ratings at the lower stimulus concentrations for all stimuli except caffeine. Moreover, regional testing found that PD subjects tended to rate the stimuli, relative to the controls, as more intense on the anterior tongue and less intense on the posterior tongue. No significant associations were evident between taste test scores and UPDRS scores, L-DOPA medication equivalency values, or [(99m)Tc]TRODAT-1 SPECT imaging of dopamine transporter uptake within the striatum and associated regions. Our findings suggest that suprathreshold measures of taste function are influenced by PD and that this disease differentially influences taste function on anterior (CN VII) and posterior (CN IX) tongue regions. Conceivably PD-related damage to CN IX releases central inhibition on CN VII at the level of the brainstem, resulting in enhanced taste intensity on the anterior tongue.

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“…The small number of PD patients involved in this group may explain the results. Kim et al (7) denied the correlation with age, duration or severity of the disease, cognitive function or olfactory function in patients with PD. The majority of reports indicate that smell impairment does not correlate with disease severity and duration (1,3,13,14).…”

Section: Discussionmentioning

confidence: 99%

“…The determined frequencies of smell impairment vary among reports based on the method of evaluation (i.e., psychophysical "Sniffin' Sticks" testing vs. electrophysiologic testing). Taste impairment has also been reported in patients with PD, but less frequently and with contradictory results (5)(6)(7). Abnormal taste includes reduced, sensitive and altered sensation and taste perception.…”

Section: Introductionmentioning

confidence: 99%

Frequency and Characteristics of Taste Impairment in Patients with Parkinson's Disease: Results of a Clinical Interview

2011

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Objective Patients with Parkinson's disease (PD) frequently complain of a diminished sense of smell. Less frequently, they may complain of taste impairment. In the present study, we investigated the symptoms, frequency, and severity of taste impairment as well as smell impairment in PD patients and compared the results with those of age-and sex-matched healthy controls. Patients and MethodsWe interviewed 285 PD patients (120 men, 165 women) without dementia or nasal problems. Control subjects comprised 61 (20 men, 41 women) healthy spouses of the PD patients. Alteration of smell and taste sense lasting more than 3 months was defined as abnormal. Results One hundred and sixteen patients with PD complained of smell impairment and 26 complained of taste impairment. Only 5 controls complained of smell impairment, and no control subjects reported taste impairment. Taste impairment was more marked in patients with smell impairment. Impaired taste included diminished taste perception in 21 patients, altered sense of taste in 4 patients and burning mouth in 1 patient. Conclusion Taste as well as smell perception is impaired in patients with PD. The frequency of smell and taste impairments tended to increase with disease progression.

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Taste function in patients with Parkinson disease

Cited by 35 publications

References 19 publications

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

Taste function in early stage treated and untreated Parkinson’s disease

Frequency and Characteristics of Taste Impairment in Patients with Parkinson's Disease: Results of a Clinical Interview

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