Taste dysfunction in head and neck malignancy

Porter, Stephen; Fedele, Stefano; Habbab, K.M.

doi:10.1016/j.oraloncology.2010.03.011

Cited by 31 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, radiation damage of salivary glands leads to severe hyposalivation, which may contribute to lessened taste acuity (de Graeff et al, 2000; Chambers et al, 2004). However, deficient salivary function is likely not a major driver of taste loss, as taste and salivary gland symptoms vary independently (see Porter et al, 2010, and references therein). In oral mucosa in general (Dorr and Weber-Frisch, 1995; Wardley et al, 1998; Potten et al, 2002), and now specifically in taste epithelium, irradiation targets proliferating cells, resulting in an insufficient supply of new cells to the epithelium and taste buds, respectively.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Taste Bud Cell Loss after Head and Neck Irradiation

Nguyen¹,

Reyland²,

Barlow³

2012

J. Neurosci.

View full text Add to dashboard Cite

Taste loss in human patients following radiotherapy for head and neck cancer is a common and significant problem, but the cellular mechanisms underlying this loss are not understood. Taste stimuli are transduced by receptor cells within taste buds, and like epidermal cells, taste cells are regularly replaced throughout adult life. This renewal relies on a progenitor cells adjacent to taste buds, which continually supply new cells to each bud. Here we treated adult mice with a single 8 Gy dose of X-ray irradiation to the head and neck, and analyzed taste epithelium at 1–21 days post-irradiation (dpi). We found irradiation targets the taste progenitor cells, which undergo cell cycle arrest (1–3 dpi) and apoptosis (within 1 dpi). Taste progenitors resume proliferation at 5–7 dpi, with the proportion of cells in S and M phase exceeding control levels at 5–6 and 6 dpi, respectively, suggesting that proliferation is accelerated and/or synchronized following radiation damage. Using BrdU birthdating to identify newborn cells, we found that the decreased proliferation following irradiation reduces the influx of cells at 1–2 dpi, while the robust proliferation detected at 6 dpi accelerates entry of new cells into taste buds. By contrast, the number of differentiated taste cells was not significantly reduced until 7 dpi. These data suggest a model where continued natural taste cell death, paired with temporary interruption of cell replacement underlies taste loss after irradiation.

show abstract

Section: Discussionmentioning

confidence: 99%

Mechanisms of Taste Bud Cell Loss after Head and Neck Irradiation

Nguyen¹,

Reyland²,

Barlow³

2012

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Um eine Grundlage für ein solches Vorgehen zu schaffen, haben wir eine systematische Erfassung des zeitlichen Auftretens von subjektiv von den Patienten empfundenen Verände-rungen des Schmeckvermögens unter IMRT vorgenommen und eine Dosis-Wirkungs-Beziehung analysiert. Einleitung ▼ Häufige akute Nebenwirkungen während der Strahlentherapie von Hals-Nasen-Ohren-Tumoren sind Mucositis, Mundtrockenheit und Verän-derungen des Schmeckvermögens [1][2][3][4]. Diese führen oft zu verminderter Nahrungsaufnahme und konsekutiver Gewichtsreduktion.…”

Section: Change Of Taste During and After Im-/ig-radiotherapy For Heaunclassified

“…Durch eine entsprechende Dosisreduktion im Bereich der Geschmacksrezeptoren wäre es denkbar, auch das Ausmaß der Veränderungen des Schmeckvermögens unter Strahlentherapie zu [1]. Veränderungen oder Verluste des Schmecksinns werden bei fast allen Patienten beschrieben, insbesondere wenn Bestrahlungsdosen über 20 Gy appliziert werden [2]. Eine Erholung stellt sich normalerweise innerhalb von 6-24 Monaten ein [4,5].…”

Section: Change Of Taste During and After Im-/ig-radiotherapy For Heaunclassified

Veränderungen des Schmeckvermögens durch IM-/IG-Strahlentherapie bei Kopf-Hals-Tumorpatienten

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Dentists are often involved in the prevention and management of these complications. Efforts are made to minimize the risk of complications through the development of new therapies such as intensity-modulated radiation therapy [5, 18-20]; use of cytoprotective agents [18-21]; and the multidisciplinary approach to treatment allowing, for example, the dental team to ensure the patient is dentally fit prior to commencement of cancer treatment and is able to maintain an optimal level of oral health in the challenging, dry mouth environment [22]. …”

Section: Introductionmentioning

confidence: 99%

“…Thus, at the time of the dental work-up, implications of radiation therapy to head and neck region need to be carefully explained as well as the importance of regular, life-long dental care. Comprehensive clinical dental examination including radiographic examination is considered essential [22, 23, 26-28]. …”

Section: Introductionmentioning

confidence: 99%

Expertise Regarding Dental Management of Oral Cancer Patients Receiving Radiation Therapy Among Western Australian Dentists

Frydrych¹,

Slack‐Smith²,

Park³

et al. 2012

TODENTJ

View full text Add to dashboard Cite

Objectives:Dental care forms an important part of the multidisciplinary management of oral cancer patients. The aim of this study was to examine actual and self-perceived knowledge and clinical expertise regarding dental management of oral cancer patients receiving radiation therapy among Western Australian general dentists.Materials and Methods:An invitation to participate in a web-based questionnaire was emailed to 1095 dentists registered with the Australian Dental Association (ADA), WA branch. To assess dentists’ knowledge and expertise, actual and perceived knowledge was investigated. Information regarding type of practice, practice location, year of graduation and number of oral cancer patients treated in the preceding 12 months was also obtained.Results:One hundred and ninety one dentists responded to the survey. General dentists who took part in the study appeared to possess some knowledge regarding dental management of oral cancer patients treated with radiation therapy. The majority of responders however identified deficiencies in their knowledge and willingness to participate in continuing education programs.Conclusion:In view of the rising incidence of oral cancer in Western Australia, efforts should be made to provide more clinically relevant training to dentists in this area.

show abstract

Taste dysfunction in head and neck malignancy

Cited by 31 publications

References 31 publications

Mechanisms of Taste Bud Cell Loss after Head and Neck Irradiation

Mechanisms of Taste Bud Cell Loss after Head and Neck Irradiation

Veränderungen des Schmeckvermögens durch IM-/IG-Strahlentherapie bei Kopf-Hals-Tumorpatienten

Expertise Regarding Dental Management of Oral Cancer Patients Receiving Radiation Therapy Among Western Australian Dentists

Contact Info

Product

Resources

About