Taste and Smell Changes in Patients Receiving Cancer Chemotherapy

Bernhardson, Britt-Marie; Tishelman, Carol; Rutqvist, Lars Erik

doi:10.1097/01.ncc.0000343368.06247.74

Cited by 58 publications

(17 citation statements)

References 92 publications

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“…Moreover, asthma was a predictor of poor olfactory function in patients with chronic rhinosinusitis 37. Some clinical studies have also demonstrated that smell function is significantly decreased in patients receiving cancer chemotherapy,38 39 and at least one study suggest that the prevalence of self-reported taste and smell alterations could reach as high as 86% 40. Of note, smoking was not associated with the prevalence of smell impairment in our cross-sectional analysis.…”

Section: Discussionmentioning

confidence: 43%

Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study

et al. 2016

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ObjectivesTo estimate the prevalence of, and explore potential risk factors for, taste and smell dysfunction in the general population of the USA.DesignA cross-sectional study.SettingA cross-sectional analysis of data collected in the National Health and Nutrition Examination Survey (NHANES 2013–2014).ParticipantsA total of 3519 men and women aged 40 years and older who participated in NHANES 2013–2014.Main outcome measuresUsing the NHANES Pocket Smell Test, smell impairment was defined as failing to correctly identify 6 or more of the 8 odours. Taste impairment was defined as failing to correctly identify quinine or sodium chloride.ResultsThe estimated prevalence was 13.5% for smell impairment, 17.3% for taste impairment and 2.2% for taste and smell impairment. For smell, but not taste, prevalence estimates increased with age and were higher in men and ethnic minorities. In backward stepwise logistic regression, low educational attainment, low family income and a history of asthma or cancer were independently associated with a higher prevalence of smell impairment, whereas light-to-moderate alcohol consumption (1–3 drinks/day) was associated with a lower prevalence of this condition. After multivariate adjustment, being non-Hispanic Black Americans, consuming ≥4 drinks of alcohol per day and having a history of cardiovascular disease (CVD) were independently associated with a higher prevalence of taste impairment.ConclusionsBased on a nationally representative multistage probability survey among the US population aged 40 years and older, smell and taste dysfunction affected ∼20.5 million (13.5%) and 26.3 million (17.3%) individuals, respectively. Age, gender, ethnicity, educational attainment, family income, light-to-moderate alcohol consumption and history of asthma or cancer were significant risk factors for smell dysfunction, whereas only ethnicity, heavy alcohol consumption and CVD history were associated with a higher prevalence of taste dysfunction.

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Section: Discussionmentioning

confidence: 43%

Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study

et al. 2016

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“…The change in taste and smell sensitivity among patients receiving chemotherapy is a well-known effect (Bernhardson, Tishelman, & Rutqvist, 2009; Duffy, Fast, Lucchina, & Bartoshuk, 2002), and these have an impact on the patient's day-to-day life (Bernhardson et al, 2009). This knowledge, together with the description from this study of the importance of fresh air and being able to inhale good, outdoor smells, demonstrates the importance of an environment that offers the chance to open a window.…”

Section: Discussionmentioning

confidence: 99%

Patients’ experience of important factors in the healthcare environment in oncology care

Browall

Koinberg

Falk

et al. 2013

International Journal of Qualitative Studies on Health and Well

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Background and objectiveThe aim of this study was to describe what factors of the healthcare environment are perceived as being important to patients in oncology care.DesignA qualitative design was adopted using focus group interviews.Setting and participantsThe sample was 11 patients with different cancer diagnoses in an oncology ward at a university hospital in west Sweden.ResultsAnalysis of the patients’ perceptions of the environment indicated a complex entity comprising several aspects. These came together in a structure consisting of three main categories: safety, partnership with the staff, and physical space. The care environment is perceived as a complex entity, made up of several physical and psychosocial aspects, where the physical factors are subordinated by the psychosocial factors. It is clearly demonstrated that the patients’ primary desire was a psychosocial environment where they were seen as a unique person; the patients wanted opportunities for good encounters with staff, fellow patients, and family members, supported by a good physical environment; and the patients valued highly a place to withdraw and rest.ConclusionsThis study presents those attributes that are valued by cancer patients as crucial and important for the support of their well-being and functioning. The results show that physical aspects were subordinate to psychosocial factors, which emerged strongly as being the most important in a caring environment.

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“…Although alteration of taste (dysgeusia) is a nonlethal condition that is often ignored, taste is critical to the pleasure of eating, which is a major part of QOL [1,2]. Dysgeusia is frequent in patients with cancer [3,4].…”

Section: Introductionmentioning

confidence: 99%

Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer

et al. 2013

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BackgroundAlthough dysgeusia is a common adverse event in chemotherapy patients; it has not been evaluated using objective methods, and its prevalence and frequency have not been quantified.MethodsSalt-impregnated taste strips were used to objectively assess dysgeusia in patients receiving chemotherapy at Akita University (n = 38) and those off chemotherapy (n = 9). Participant characteristics, and ongoing and previous chemotherapies were evaluated, and their associations with dysgeusia analyzed.ResultsDysgeusia developed in 38.8% (14/38) of chemotherapy patients, and was most prevalent in patients receiving 5-fluorouracil (5-FU) or its oral analogs (48.1%, 13/27). Particularly, dysgeusia developed in 55.6% (10/18) of patients receiving oral 5-FU analogs; however, prevalence in patients receiving and off chemotherapy was not significantly different. Patients aged ≥70 years also tended to experience dysgeusia (75.0%, 6/8).ConclusionsAssociation with dysgeusia may be higher for some chemotherapeutic drugs. Dysgeusia should be routinely assessed in chemotherapy patients with objective methods such as paper strips; interventions for its prevention may be required.

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Taste and Smell Changes in Patients Receiving Cancer Chemotherapy

Cited by 58 publications

References 92 publications

Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study

Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study

Patients’ experience of important factors in the healthcare environment in oncology care

Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer

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