Task specific influences of Parkinson’s disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries

Lewis, Mechelle M.; Slagle, C.G.; Smith, Anna; Truong, Young K.; Bai, Ping; McKeown, Martin J.; Mailman, Richard B.; Belger, Ayşenil; Huang, Xi Ping

doi:10.1016/j.neuroscience.2007.04.006

Cited by 114 publications

(103 citation statements)

References 37 publications

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“…Consequently, these produce enhancement of the neural processing mechanisms required for proper task performance [45,46]. This comes in agreement with Wright and Shea [47] who concluded that attention is critical for the development of motor control.…”

Section: Discussionsupporting

confidence: 80%

Efficacy of Concurrent Cognitive-Motor Training on Gait in Hemiparetic Cerebral Palsy: A Randomized Controlled Trial

Gharib¹,

Maksoud²,

Elsayed³

2017

IJPR

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Background: Interference between cognitive tasks and motor control activities such as walking is crucial for functional enhancement in patients with neurological disorders. Therefore, both cognitive and motor training should be addressed in planning physical therapy programs. Objective:To assess the efficacy of concurrent cognitive-motor training on gait in children with hemiparetic cerebral palsy. Materials and Methods:Thirty children with hemiparetic cerebral palsy of both sexes (10-14 years) shared in this study. They were randomly assigned into two equal groups; experimental and control groups. Children in the experimental group received a traditional physical therapy exercise program in addition to a gait training program given concurrently with cognitive tasks. Those in the control group received the same traditional physical therapy and gait training programs without any concurrent cognitive tasks. Treatment was provided three times per week for three successive months. The participants received baseline and post-treatment assessments for dimension E of Gross Motor Function Measure (GMFM) and some gait parameters including: step length, walking speed, ambulation index and time of support on the affected side (% of gait cycle).Results: Children in both groups showed significant improvement post treatment in GMFM scores and all measured gait parameters (p<0.05) with a higher improvement in the experimental group. After the intervention, between-group comparison revealed significant differences for ambulation index (t=3.16, p=0.004) and time of support on the affected side (t=3.61, p=0.001) in favour of the experimental group. No significant between-group differences were found in GMFS scores, step length and walking speed (p > 0.05). Conclusion:Concurrent cognitive-motor training increased the chance of improving walking ability in children with hemiparetic cerebral palsy as compared to the motor training alone.

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Section: Discussionsupporting

confidence: 80%

Efficacy of Concurrent Cognitive-Motor Training on Gait in Hemiparetic Cerebral Palsy: A Randomized Controlled Trial

Gharib¹,

Maksoud²,

Elsayed³

2017

IJPR

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“…In addition, the thalamus [39] and the globus pallidus [40] were, according to our first hypothesis, also activated after ACUP on GB 34; however, this was only the case in healthy participants. More specifically, in healthy participants, it was found that almost all brain activation occurred in the basal ganglia.…”

Section: Discussionmentioning

confidence: 62%

“…However, it remains unclear why the effect of acupuncture on GB 34 is visible in the prefrontal cortex and precentral gyrus and not in the thalamus, globus pallidus, and caudate, which are areas that are also known to be affected by PD [38,39,41]. In previous studies [63,65], it was found that the prefrontal cortex and precentral gyrus were impaired in patients with PD when conducting motor tasks and that these areas are related to motor function.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the literature, we hypothesize that acupuncture stimulation on GB 34 has an effect on brain areas that are known to show dysfunction due to nigral dopamine depletion: the prefrontal cortex [37], precentral gyrus [38], thalamus [39], globus pallidus [40], caudate [41], and putamen [38]. Moreover, our second hypothesis is that a significant difference in brain activity in patients with PD compared with healthy participants will be found.…”

Section: Introductionmentioning

confidence: 96%

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A Case Report of Drug-Induced Parkinsonism Treated with Jodeung-san and Electro-acupuncture at GB34

Kim¹,

Song²,

Kim³

et al. 2017

J Int Korean Med

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Background: Acupuncture is increasingly used as an additional treatment for patients with Parkinson's disease (PD). Methods: In this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy participants. Acupuncture was conducted on a specific acupoint, the right GB 34 (Yanglingquan), which is a frequently used acupoint for motor function treatment in the oriental medical field.Results: Acupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially visible in the left hemisphere. Conclusions:The neuroimaging results of our study suggest that in future acupuncture research; the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of Parkinson's disease and that GB 34 seems to be a suitable acupoint. Moreover, acupuncture evoked different brain activations in patients with Parkinson's disease than in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture efficacy.Trial registration: KCT0001122 at cris.nih.go.kr (registration date: 20140530)

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“…Regions examined included bilateral caudate, lentiform nucleus, thalamus, supplementary motor area (SMA), primary motor cortex (PMC), prefrontal cortex (PFC), and cerebellar hemisphere. We note that the rater reliability of the drawn ROIs was demonstrated in an earlier publication [20] by the high degree of correlation between the segmentations of the same ROIs extracted twice, once predrug and once postdrug administration on a pair of twins, one of whom has Parkinson's disease (PD).…”

Section: Fmri Preprocessing and Statistical Map Generationmentioning

confidence: 88%

Spatial Characterization of fMRI Activation Maps Using Invariant 3-D Moment Descriptors

Abugharbieh

Huang

et al. 2009

IEEE Trans. Med. Imaging

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Abstract-A novel approach is proposed for quantitatively characterizing the spatial patterns of activation statistics in functional magnetic resonance imaging (fMRI) activation maps. Specifically, we propose using 3-D invariant moment descriptors, as opposed to the traditionally-employed magnitude-based features such as mean voxel statistics or percentage of activated voxels, to characterize the task-specific spatial distribution of activation statistics within a given region of interest (ROI). The proposed method is applied to real fMRI data collected from 21 healthy subjects performing previously-learned right-handed finger tapping sequences that are either externally guided (EG) by a cue or internally guided (IG)-tasks expected to incur subtle differences in motor-related cortical and subcortical ROIs. Voxel-based activation statistics contrasting EG versus rest and IG versus rest are examined in multiple manually-drawn ROIs on unwarped brain images. Analyzing the activation statistics within each ROI using the proposed 3-D invariant moment descriptors detected significant group differences between the two tasks, thus quantitatively demonstrating that the spatial distribution of activation statistics within an ROI represent an important task-related attribute of brain activation. In contrast, conventional methods that solely rely on activation statistic magnitudes and disregard spatial information showed reduced discriminability. Normally, incorporating spatial information would merely increase inter-subject variability partly due to differences in brain size and subject's orientation in the scanner. Yet, our results suggest that the proposed spatial features, which are invariant to similarity transformations, can effectively account for such inter-subject variability, while enhancing the sensitivity in detecting task-specific activation. Thus, we argue that this novel quantitative description of the "3-D texture" of activation maps provides new directions to explore for ROI-based fMRI analysis.Index Terms-Brain imaging, functional magnetic resonance imaging (fMRI) ROI characterization, spatial fMRI analysis, three-dimensional (3-D) invariant moment descriptors.

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Task specific influences of Parkinson’s disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries

Cited by 114 publications

References 37 publications

Efficacy of Concurrent Cognitive-Motor Training on Gait in Hemiparetic Cerebral Palsy: A Randomized Controlled Trial

Efficacy of Concurrent Cognitive-Motor Training on Gait in Hemiparetic Cerebral Palsy: A Randomized Controlled Trial

A Case Report of Drug-Induced Parkinsonism Treated with Jodeung-san and Electro-acupuncture at GB34

Spatial Characterization of fMRI Activation Maps Using Invariant 3-D Moment Descriptors

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