Task-specific deactivation patterns in functional magnetic resonance imaging

Hutchinson, Michael; Schiffer, Wynne K.; Joseffer, Seth S.; Liu, A; Schlößer, R.; Dikshit, S; Goldberg, Elkhonon; Brodie, Jonathan D.

doi:10.1016/s0730-725x(99)00093-4

Cited by 67 publications

(46 citation statements)

References 24 publications

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“…As already noted above, the activation pattern in pIC was opposite for the experience and observation of affective touch (for discussions about task-related deactivations, see Fransson, Krüger, Merboldt, & Frahm, 1999;Hutchinson et al, 1999). In this case, one could argue that this might be due to an expectancy-based incongruence between visual (i.e., touch) and tactile input (i.e., no touch).…”

Section: Deactivation Of Pic During Touch Observationmentioning

confidence: 87%

Differential Involvement of Somatosensory and Interoceptive Cortices during the Observation of Affective Touch

Ebisch

Ferri

Salone

et al. 2011

Journal of Cognitive Neuroscience

115

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Abstract■ Previous studies suggested that the observation of other individualsʼ somatosensory experiences also activates brain circuits processing oneʼs own somatosensory experiences. However, it is unclear whether cortical regions involved with the elementary stages of touch processing are also involved in the automatic coding of the affective consequences of observed touch and to which extent they show overlapping activation for somatosensory experiences of self and others. In order to investigate these issues, in the present functional magnetic resonance imaging study, healthy participants either experienced touch or watched videos depicting other individualsʼ inanimate and animate/social touch experiences. Essentially, a distinction can be made between exteroceptive and interoceptive components of touch processing, involved with physical stimulus characteristics and internal feeling states, respectively. Consistent with this distinction, a specific negative modulation was found in the posterior insula by the mere visual perception of other individualsʼ social or affective cutaneous experiences, compared to neutral inanimate touch. On the other hand, activation in secondary somatosensory and posterior superior temporal regions, strongest for the most intense stimuli, seemed more dependent on the observed physical stimulus characteristics. In contrast to the detected vicarious activation in somatosensory regions, opposite activation patterns for the experience (positive modulation) and observation (negative modulation) of touch suggest that the posterior insula does not reflect a shared representation of self and othersʼ experiences. Embedded in a distributed network of brain regions underpinning a sense of the bodily self, the posterior insula rather appears to differentiate between self and other conditions when affective experiences are implicated. ■

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Section: Deactivation Of Pic During Touch Observationmentioning

confidence: 87%

Differential Involvement of Somatosensory and Interoceptive Cortices during the Observation of Affective Touch

Ebisch

Ferri

Salone

et al. 2011

Journal of Cognitive Neuroscience

115

View full text Add to dashboard Cite

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“…Contrast values are estimates of the difference in activation between the conditions: a positive contrast value for a voxel is interpreted as an increase in brain activation for the second condition compared to the first, whereas a negative value is often assumed to reflect a decrease [1,9]. The statistical test applied in this work is the t-test, which determines the probability that the means of two sets of samples with Gaussian distributions are different.…”

Section: Methodsmentioning

confidence: 99%

Patient Classification of fMRI Activation Maps

Ford

Farid

Makedon

et al. 2003

Lecture Notes in Computer Science

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Abstract. The analysis of brain activations using functional magnetic resonance imaging (fMRI) is an active area of neuropsychological research. Standard techniques for analysis have traditionally focused on finding the most significant areas of brain activation, and have only recently begun to explore the importance of their spatial characteristics. We compare fMRI contrast images and significance maps to training sets of similar maps using the spatial distribution of activation values. We demonstrate that a Fisher linear discriminant (FLD) classifier for either type of map can differentiate patients from controls accurately for Alzheimer's disease, schizophrenia, and mild traumatic brain injury (MTBI).

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“…We used 2 well-characterized functional polymorphisms (COMT Val158Met and DAT 3Ј UTR VNTR) and functional MRI to study healthy volunteers and patients with schizophrenia, with genotype subgroups of sufficient size to detect interactive effects of both genes on activation by using an ANOVA. Subjects were scanned while they performed an overt phonological verbal fluency paradigm, which is associated with activation in the frontal, cingulate, and temporal cortex in healthy volunteers (46)(47)(48)(49)(50)(51)(52)(53)(54), and with impaired performance (55,56) and altered activation (51,54,(57)(58)(59)(60) in schizophrenia. On the basis of evidence that variation in DAT (at the 3Ј UTR VNTR) and in COMT (at the Val158Met SNP) separately modulate fronto-temporal activation during verbal fluency, and that these effects are altered in patients with schizophrenia (27, 84), we predicted that there would be an epistatic interaction between their effects on regional activation in the same sample and paradigm.…”

mentioning

confidence: 99%

Epistasis between the DAT 3′ UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia

Prata

Mechelli

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Dopamine has a crucial role in the modulation of neurocognitive function, and synaptic dopamine activity is normally regulated by the dopamine transporter (DAT) and catechol-O-methyltransferase (COMT). Perturbed dopamine function is a key pathophysiological feature of schizophrenia. Our objectives were (i) to examine epistasis between the DAT 3 UTR variable number of tandem repeats (VNTR) and COMT Val158Met polymorphisms on brain activation during executive function, and (ii) to then determine the extent to which such interaction is altered in schizophrenia. Regional brain response was measured by using blood-oxygen-level-dependent fMRI during an overt verbal fluency task in 85 subjects (44 healthy volunteers and 41 patients with DSM-IV schizophrenia), and inferences were estimated by using an ANOVA in SPM5. There was a significant COMT ؋ DAT nonadditive interaction effect on activation in the left supramarginal gyrus, irrespective of diagnostic group (Z-score ‫؍‬ 4.3; familywise error (FWE) p ‫؍‬ 0.03), and in healthy volunteers alone (Z-score ‫؍‬ 4.7; FWEp ‫؍‬ 0.006). In this region, relatively increased activation was detected only when COMT Met-158/Met-158 subjects also carried the 9-repeat DAT allele, or when, reversely, Val-158/Val-158 subjects carried the 10/10-repeat genotype. Also, there was a significant diagnosis ؋ COMT ؋ DAT nonadditive interaction in the right orbital gyrus (Z-score ‫؍‬ 4.3; FWEp ‫؍‬ 0.04), where, only within patients, greater activation was only associated with a 9-repeat allele and Val-158 conjunction, and with a 10-repeat and Met-158 conjunction (Z-score ‫؍‬ 4.3; FWE p ‫؍‬ 0.04). These data demonstrate that COMT and DAT genes interact nonadditively to modulate cortical function during executive processing, and also, that this effect is significantly altered in schizophrenia, which may reflect abnormal dopamine function in the disorder.

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Task-specific deactivation patterns in functional magnetic resonance imaging

Cited by 67 publications

References 24 publications

Differential Involvement of Somatosensory and Interoceptive Cortices during the Observation of Affective Touch

Differential Involvement of Somatosensory and Interoceptive Cortices during the Observation of Affective Touch

Patient Classification of fMRI Activation Maps

Epistasis between the DAT 3′ UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia

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