Task-rest modulation of basal ganglia connectivity in mild to moderate Parkinson’s disease

Müller‐Oehring, Eva M.; Sullivan, Edith V.; Pfefferbaum, Adolf; Huang, Ning; Poston, Kathleen L.; Brontë‐Stewart, Helen; Schulte, Tilman

doi:10.1007/s11682-014-9317-9

Cited by 27 publications

(17 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To quantify Stroop effects within a block design, incongruent and congruent trials were never mixed within a block. Consistent with our experience with previous task versions of the Stroop Match-to-Sample task (Müller-Oehring et al 2013; Müller-Oehring et al 2015a, b; Schulte et al 2005; Schulte et al 2011; Schulte et al 2012), subjects were not aware about the blocked trial design, as indicated in post-scan interviews.…”

Section: Methodsmentioning

confidence: 71%

The neural correlates of priming emotion and reward systems for conflict processing in alcoholics

Schulte

Jung

Sullivan

et al. 2016

Brain Imaging and Behavior

View full text Add to dashboard Cite

Emotional dysregulation in alcoholism (ALC) may result from disturbed inhibitory mechanisms. We therefore tested emotion and alcohol cue reactivity and inhibitory processes using negative priming. To test the neural correlates of cue reactivity and negative priming, 26 ALC and 26 age-matched controls underwent functional MRI performing a Stroop color match-to-sample task. In cue reactivity trials, task-irrelevant emotion and alcohol-related pictures were interspersed between color samples and color words. In negative priming trials, pictures primed the semantic content of an alcohol or emotion Stroop word. Behaviorally, both groups showed response facilitation to picture cue trials and response inhibition to primed trials. For cue reactivity to emotion and alcohol pictures, ALC showed midbrain-limbic activation. By contrast, controls activated frontoparietal executive control regions. Greater midbrain-hippocampal activation in ALC correlated with higher amounts of lifetime alcohol consumption and higher anxiety. With negative priming, ALC exhibited frontal cortical but not midbrain-hippocampal activation, similar to the pattern observed in controls. Higher frontal activation to alcohol-priming correlated with less craving and to emotion-priming with fewer depressive symptoms. The findings suggest that neurofunctional systems in ALC can be primed to deal with upcoming emotion- and alcohol-related conflict and can overcome the prepotent midbrain-limbic cue reactivity response.

show abstract

Section: Methodsmentioning

confidence: 71%

The neural correlates of priming emotion and reward systems for conflict processing in alcoholics

Schulte

Jung

Sullivan

et al. 2016

Brain Imaging and Behavior

View full text Add to dashboard Cite

show abstract

“…Strong evidence suggests that the output of the basal ganglia, mainly the globus pallidus interna, is hyperactive in PD [68] and our results of increased FC with this area suggest that increased activity may be accompanied by increased FC. Increased FC between the caudate nuclei and the thalamus has been shown in a PD cohort on medication [69], however two studies have demonstrated conflicting results [17,70]. A crucial difference separating these studies relates is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.…”

Section: Discussionmentioning

confidence: 99%

Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease

Owens‐Walton

Jakabek

Power

et al. 2019

Preprint

View full text Add to dashboard Cite

Parkinson's disease (PD) affects 2-3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was to more clearly elucidate how functional connectivity and morphology of the thalamus are impacted in PD (n = 32) compared to Controls (n = 20). To investigate functional connectivity of the thalamus we subdivided the structure into two important regions-of-interest, the first with putative connections to the motor cortices and the second with putative connections to prefrontal cortices. We then investigated potential differences in the size and shape of the thalamus in PD, and how morphology and functional connectivity relate to clinical variables. Our data demonstrate that PD is associated with increases in functional connectivity between motor subdivisions of the thalamus and the supplementary motor area, and between prefrontal thalamic subdivisions and nuclei of the basal ganglia, anterior and dorsolateral prefrontal cortices, as well as the anterior and paracingulate gyri. These results suggest that PD is associated with increased functional connectivity of subdivisions of the thalamus which may be indicative alterations to basal ganglia-thalamocortical circuitry.

show abstract

“…Particularly germane to the present topic, animal models have led to important findings on neural substrates mediating addiction to multiple substances of abuse (c.f., Bell and Rahman, 2016; De Biasi, 2015; Dwoskin, 2014; Ekhtiari and Paulus, 2016a, 2016b; Frascella et al, 2011; Heidbreder, 2008; Koob et al, 2014a; McArthur and Borsini, 2008c; Nader, 2016; Olmstead, 2011) and ethanol in particular (Bell et al, 2005, 2006b, 2012, 2013, 2014, 2016; Ciccocioppo, 2013; Crabbe et al, 2013; Knapp and Breese, 2012; Maldonado-Devincci et al, 2012; McBride and Li, 1998; McBride et al, 2014b; Ramsden, 2015; Ryabinin, 2012). As indicated above, advanced neuroimaging techniques including resting state functional connectivity are being used to develop endophenotypes for medications development targeting AUDs (e.g., Brown et al, 2015; Cui et al, 2015; Ernst et al, 2015; Fedota and Stein, 2015; Gowin et al, 2015; Gullo et al, 2011; Moeller et al, 2016; Muller-Oehring et al, 2015a, 2015b; Schuckit et al, 2016; Squeglia et al, 2014). In general, an animal model has the advantage of allowing the experimenter to control factors such as the animal's genetic background, environment, and drug exposure.…”

Section: Background From An Animal Model Perspectivementioning

confidence: 99%

Rat animal models for screening medications to treat alcohol use disorders

et al. 2017

View full text Add to dashboard Cite

The purpose of this review is to present animal research models that can be used to screen and/or repurpose medications for the treatment of alcohol abuse and dependence. The focus will be on rats and in particular selectively bred rats. Brief introductions discuss various aspects of the clinical picture, which provide characteristics of individuals with alcohol use disorders (AUDs) to model in animals. Following this, multiple selectively bred rat lines will be described and evaluated in the context of animal models used to screen medications to treat AUDs. Next, common behavioral tests for drug efficacy will be discussed particularly as they relate to stages in the addiction cycle. Tables highlighting studies that have tested the effects of compounds using the respective techniques are included. Wherever possible the Tables are organized chronologically in ascending order to describe changes in the focus of research on AUDs over time. In general, high ethanol-consuming selectively bred rats have been used to test a wide range of compounds. Older studies usually followed neurobiological findings in the selected lines that supported an association with a propensity for high ethanol intake. Most of these tests evaluated the compound's effects on the maintenance of ethanol drinking. Very few compounds have been tested during ethanol-seeking and/or relapse and fewer still have assessed their effects during the acquisition of AUDs. Overall, while a substantial number of neurotransmitter and neuromodulatory system targets have been assessed; the roles of sex- and age-of-animal, as well as the acquisition of AUDs, ethanol-seeking and relapse continue to be factors and behaviors needing further study.

show abstract

Task-rest modulation of basal ganglia connectivity in mild to moderate Parkinson’s disease

Cited by 27 publications

References 104 publications

The neural correlates of priming emotion and reward systems for conflict processing in alcoholics

The neural correlates of priming emotion and reward systems for conflict processing in alcoholics

Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease

Rat animal models for screening medications to treat alcohol use disorders

Contact Info

Product

Resources

About