Task-related neural activation abnormalities in patients with remitted major depressive disorder: A coordinate-based meta-analysis

Wang, Zuxing; Zou, Zhili; Xiao, Jun; Wang, Peijia; Luo, Yuanyuan; Min, Wenjiao; He, Ying; Yuan, Cui; Su, Yihan; Yang, Chenghui; Cheng, Fan; Zhu, Hongru

doi:10.1016/j.neubiorev.2022.104929

Cited by 8 publications

(6 citation statements)

References 65 publications

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“…Similar to previous task-related fMRI meta-analyses of rMDD patients (Wang et al, 2022), our results presented that compared with HCs, patients with rMDD showed significantly abnormal neural activaty in the left inferior parietal gyrus, left SFG, and right MTG, which play an important role in sensory perception, emotional control and cognitive functions, respectively. At present, the emotion regulation theory (van Kleef et al, 2022), and the cognitive model theory (Disner et al, 2011) are main hypotheses about the neuropathological mechanism of depression.…”

Section: Comparison Of Rmdd Patients and Hcssupporting

confidence: 90%

“…Thanks to better public understanding of MDD and improvements in medical technology, many people suffering from MDD have been able to find complete relief through systematic treatment (Smoski et al, 2013; Wang et al, 2022). Although patients with MDD have shown improvement according to a clinical symptom evaluation, individuals with remitted MDD (rMDD) still demonstrate differences in cognitive function, neuroimaging, and metabolism when compared to healthy controls (HCs) (Moriarty et al, 2022; van Kleef et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…To date, heterogeneity, small sample sizes and differences in analytical methods (e.g., region-of-interest (ROI) or whole-brain analyses) have resulted in inconsistency in data collection and analysis. Previous meta-analyses of MDD and rMDD found many neural activation changes, such as changes in the superior temporal gyrus (STG), prefrontal cortex, insula, striatum, middle temporal gyrus (MTG), superior frontal gyrus and limbic system (Gong et al, 2020; Palmer et al, 2014; Wang et al, 2022). However, it is unclear whether alterations in neural activation can differentiate MDD from rMDD or whether common abnormalities are present in MDD patients in both the current and remitted states.…”

Section: Introductionmentioning

confidence: 99%

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Common And Distinct Patterns Of Task-Related Neural Activation Abnormalities In Patients With Remitted And Current Major Depressive Disorder: A Systematic Review And Coordinate-Based Meta-Analysis

Wang

et al. 2023

Preprint

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Whether remitted major depressive disorder (rMDD) and MDD present common or distinct neuropathological mechanisms remains unclear. We performed a meta-analysis of task-related whole-brain functional magnetic resonance imaging (fMRI) using anisotropic effect-size signed differential mapping software to compare brain activation between rMDD/MDD patients and healthy controls (HCs). We included 18 rMDD studies (458 patients and 476 HCs) and 120 MDD studies (3746 patients and 3863 HCs). The results showed that MDD and rMDD patients shared increased neural activation in the right temporal pole and right superior temporal gyrus. Several brain regions, including the right middle temporal gyrus, left inferior parietal, prefrontal cortex, left superior frontal gyrus and striatum, differed significantly between MDD and rMDD. Meta-regression analyses revealed that the percentage of females with MDD was positively associated with brain activity in the right lenticular nucleus/putamen. Our meta-analysis provides useful insights for understanding the potential neuropathology of brain dysfunction in MDD, developing more targeted and efficacious treatment and intervention strategies, and more importantly, providing potential neuroimaging targets for early screening of MDD.

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Section: Comparison Of Rmdd Patients and Hcssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Common And Distinct Patterns Of Task-Related Neural Activation Abnormalities In Patients With Remitted And Current Major Depressive Disorder: A Systematic Review And Coordinate-Based Meta-Analysis

Wang

et al. 2023

Preprint

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“…Results from a meta-analysis of fMRI studies investigating emotional processing in MDD have shown that the activity of the MTG is altered in MDD patients during emotional processing . Another meta-analysis revealed abnormal task-related activity in the MTG in rMDD patients (Wang, Zou et al, 2022). Yet another meta-analysis documented a hyperconnectivity between the MTG and the PCC in MDD (Zhu et al, 2022).…”

Section: Dmn Regionsmentioning

confidence: 99%

The Habenula in Mood Disorders: A Scoping Review of Human Studies

Fortin,

Lafleur,

Parisien

et al. 2024

Preprint

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In animal models, the habenula has been identified as a key structure involved in depression. Thanks to recent technological advancements, a burgeoning body of work has also investigated the habenula in the context of human mood disorders. This scoping review aims to synthesize findings from human studies that pertain to the habenula and its relationship with mood disorders. The review was conducted according to PRISMA guidelines. The literature search was performed with PubMed and yielded 93 articles, of which 50 articles were included in the review. We found that the evidence for baseline habenular hyperactivity in human depression is mixed. As for findings from resting-state functional connectivity (RSFC) studies, they were mainly inconsistent across studies. Moreover, we found no evidence indicating that mood disorders are linked to changes in the volume of the habenula. In order to enhance the replicability of findings, given the small size of the habenula, higher image resolution and larger samples are recommended for future studies.

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“…Additionally, trauma in patients with MDD is negatively correlated with the cortex thickness of the left MTG [111] and bilateral MTG activity [112]. Brain activity in the right MTG was also reportedly reduced in patients with remitted MDD [113]. Moreover, behavioral experiments have confirmed that rumination is positively correlated with auditory hallucination [114], and neuroimaging studies have revealed that rumination and auditory hallucinations were both correlated with structural and functional abnormalities of the STG [115,116].…”

Section: Gmv Abnormalities In the Right Temporal Lobe Inmentioning

confidence: 99%

Meta-Analysis of Brain Volumetric Abnormalities in Patients with Remitted Major Depressive Disorder

Xu,

Zhou,

Wen

et al. 2024

Depression and Anxiety

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Although patients with major depressive disorder (MDD) achieve remission after antidepressant treatment, >90% of those in remission have at least one residual depressive symptom, which may be due to neural damage linked with MDD. To better understand the structural impairments in patients with remitted MDD, we conducted a meta-analysis comparing grey matter volume (GMV) abnormalities between patients with remitted MDD and healthy controls (HCs). There were 11 cross-sectional datasets that investigated 275 patients with remitted MDD versus 437 HCs, and 7 longitudinal datasets that investigated 167 patients with remitted MDD. We found that GMV in the left insula, inferior parietal gyri, amygdala, and right superior parietal gyrus was decreased in patients with remitted MDD than in HCs. Additionally, patients with remitted MDD had lower GMV in the bilateral gyrus rectus than those in the nonremission state. Moreover, increased GMV in the bilateral anterior cingulate cortex, right striatum, middle temporal gyrus, and superior frontal gyrus was observed in patients with remitted MDD than in HCs. Furthermore, patients with remitted MDD had a larger GMV in the bilateral median cingulate/paracingulate gyri, left striatum, putamen, amygdala, hippocampus, and parahippocampal gyrus at follow-up than at baseline. Based on the brain morphological abnormalities in patients with remitted MDD after electroconvulsive therapy and pharmacological treatment, we proposed a schematic diagram of targeted intervention approaches for residual symptoms. In summary, our findings provide neurobiology-based evidence for multitarget treatment of depression to reduce residual symptoms and improve social function in patients with MDD.

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Task-related neural activation abnormalities in patients with remitted major depressive disorder: A coordinate-based meta-analysis

Cited by 8 publications

References 65 publications

Common And Distinct Patterns Of Task-Related Neural Activation Abnormalities In Patients With Remitted And Current Major Depressive Disorder: A Systematic Review And Coordinate-Based Meta-Analysis

Common And Distinct Patterns Of Task-Related Neural Activation Abnormalities In Patients With Remitted And Current Major Depressive Disorder: A Systematic Review And Coordinate-Based Meta-Analysis

The Habenula in Mood Disorders: A Scoping Review of Human Studies

Meta-Analysis of Brain Volumetric Abnormalities in Patients with Remitted Major Depressive Disorder

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