Task-related fronto-striatal functional connectivity during working memory performance in schizophrenia

Quidé, Yann; Morris, Richard W.; Shepherd, Alana M.; Rowland, Jesseca E.; Green, Melissa

doi:10.1016/j.schres.2013.08.009

Cited by 78 publications

(62 citation statements)

References 71 publications

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“…Further, as with proactive cognitive control, there is evidence suggesting a key role for impaired connectivity between DLPFC and other WM related regions (e.g., parietal cortex, thalamus and striatum) in explaining WM impairments in schizophrenia (51)(52)(53)(54)(55), as well as evidence for altered gamma and theta oscillatory activity in prefrontal regions associated with WM impairments in this disorder (e.g., [56][57][58].…”

Section: Prefrontal Recruitment During Working Memory In Schizophreniamentioning

confidence: 99%

Cognitive impairments in psychotic disorders: common mechanisms and measurement

2014

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Decades of research have provided robust evidence of cognitive impairments in psychotic disorders. Individuals with schizophrenia appear to be impaired on the majority of neuropsychological tasks, leading some researchers to argue for a "generalized deficit", in which the multitude of cognitive impairments are the result of a common neurobiological source. One such common mechanism may be an inability to actively represent goal information in working memory as a means to guide behavior, with the associated neurobiological impairment being a disturbance in the function of the dorsolateral prefrontal cortex. Here, we provide a discussion of the evidence for such impairment in schizophrenia, and how it manifests in domains typically referred to as cognitive control, working memory and episodic memory. We also briefly discuss cognitive impairment in affective psychoses, reporting that the degree of impairment is worse in schizophrenia than in bipolar disorder and psychotic major depression, but the profile of impairment is similar, possibly reflecting common mechanisms at the neural level. Given the recent release of the DSM-5, we end with a brief discussion on assessing cognition in the context of diagnosis and treatment planning in psychotic disorders.

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Section: Prefrontal Recruitment During Working Memory In Schizophreniamentioning

confidence: 99%

Cognitive impairments in psychotic disorders: common mechanisms and measurement

2014

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“…We administered an n-back task 28 during a functional imaging paradigm to assess working memory ability (see the study by Quidé and colleagues 13 ). Participants were shown a pseudorandomized sequence of numbers (1-4) every 1800 ms and were asked to recall the number presented 2 stimulus trials previously (2-back, presented 3600 ms prior).…”

Section: Working Memory Subtypesmentioning

confidence: 99%

Shared intermediate phenotypes for schizophrenia and bipolar disorder: neuroanatomical features of subtypes distinguished by executive dysfunction

Shepherd

Quidé

Laurens

et al. 2015

jpn

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“…Activation of the ventral striatum and the PFC during reward processing is reduced in schizophrenia [21,22], and critical dysfunction of cortico-striatal connectivity related to information retrieval is observed during working memory performance in patients with schizophrenia [23]. The caudate nucleus and cortical regions connected to the caudate show markedly abnormal hemispheric specialization in patients with schizophrenia, and patients also show weaker specialization in the left caudate and stronger specialization in the right on rsfMRI.…”

Section: Introductionmentioning

confidence: 99%

Functional Connectivity of the Caudate in Schizophrenia Evaluated with Simultaneous Resting-State Functional MRI and Electroencephalography Recordings

et al. 2018

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Background: Aberrant functional connectivity (FC) is increasingly implicated in the clinical phenomenology of schizophrenia. This study focused on the FC of the cortico-striatal network, which is thought to be disrupted in schizophrenia and to contribute to its clinical manifestations. Methods: We used simultaneous resting-state functional magnetic resonance imaging (rsfMRI) and electroencephalography (EEG) recordings to investigate FC in patients with schizophrenia. The study included 20 patients with schizophrenia and 20 healthy controls (HCs). Simultaneously recorded rsfMRI and EEG data were collected with an MR-compatible amplifier, and rsfMRI data were analyzed with the CONN toolbox to calculate FC. The study focused on the caudate, which was defined as the seed. We also performed between-group comparisons of standardized low-resolution electromagnetic tomography intracortical lagged coherence for each EEG frequency band. Results: Compared to HCs, patients with schizophrenia showed enhanced FC between the caudate nucleus and the posterior cingulate cortex, temporal, and occipital regions on rsfMRI. It is thus possible that HCs have negative FC between these regions, whereas patients with schizophrenia have non-negative FC. The EEG results showed no significant differences in oscillations or in FC between the groups in any frequency band in any region. Conclusions: Increased FC in the caudate may represent aberrant between-network FC resulting from the disruption of segregation between networks.

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Task-related fronto-striatal functional connectivity during working memory performance in schizophrenia

Cited by 78 publications

References 71 publications

Cognitive impairments in psychotic disorders: common mechanisms and measurement

Cognitive impairments in psychotic disorders: common mechanisms and measurement

Shared intermediate phenotypes for schizophrenia and bipolar disorder: neuroanatomical features of subtypes distinguished by executive dysfunction

Functional Connectivity of the Caudate in Schizophrenia Evaluated with Simultaneous Resting-State Functional MRI and Electroencephalography Recordings

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