Task-based optimization and performance assessment in optical coherence imaging

Rolland, Jannick P.; O'Daniel, Jason K.; Akcay, Ceyhun; Delemos, Tony; Lee, Kye S.; Cheong, Kit Iu; Clarkson, Eric; Chakrabarti, Ratna; Ferris, Robert L.

doi:10.1364/josaa.22.001132

Cited by 25 publications

(28 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Statistical decision theory was introduced into time domain OCT for classification tasks [6,7]. We recently reported on key results of using statistical decision theory to estimate tear film thickness [8].…”

Section: Introductionmentioning

confidence: 99%

Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics

Huang¹,

Clarkson²,

Kupinski³

et al. 2013

Biomed. Opt. Express

Self Cite

View full text Add to dashboard Cite

Understanding tear film dynamics is a prerequisite for advancing the management of Dry Eye Disease (DED). In this paper, we discuss the use of optical coherence tomography (OCT) and statistical decision theory to analyze the tear film dynamics of a digital phantom. We implement a maximum-likelihood (ML) estimator to interpret OCT data based on mathematical models of Fourier-Domain OCT and the tear film. With the methodology of task-based assessment, we quantify the tradeoffs among key imaging system parameters. We find, on the assumption that the broadband light source is characterized by circular Gaussian statistics, ML estimates of 40 nm +/− 4 nm for an axial resolution of 1 μm and an integration time of 5 μs. Finally, the estimator is validated with a digital phantom of tear film dynamics, which reveals estimates of nanometer precision. Ferris, "Task-based optimization and performance assessment in optical coherence imaging," J. Opt. Soc. Am. A 22(6), 1132-1142 (2005). 7. A. C. Akcay, E. Clarkson, and J. P. Rolland, "Effect of source spectral shape on task-based assessment of detection and resolution in optical coherence tomography," Appl. Opt. 44(35), 7573-7580 (2005). 8.

show abstract

Section: Introductionmentioning

confidence: 99%

Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics

Huang¹,

Clarkson²,

Kupinski³

et al. 2013

Biomed. Opt. Express

Self Cite

View full text Add to dashboard Cite

show abstract

“…the amount of light reflected, absorbed, and scattered are generally polarization dependent [10]. The temporal coherence plays an important role in some imaging applications as it represents the axial point spread function of the imaging system as for example in Optical Coherence Tomography (OCT) [11][12][13] and Optical Coherence Microscopy (OCM) [14]. Both polarization and coherence can be changed when a light beam propagates through the medium, e.g.…”

Section: Discussionmentioning

confidence: 99%

Determination of the coherency matrix of a broadband stochastic electromagnetic light beam

Meemon

Salem

Lee

et al. 2008

Journal of Modern Optics

View full text Add to dashboard Cite

The statistical ensemble of a fluctuating, statistically-stationary electromagnetic light beam is presented in terms of a 2 Â 2 matrix, so-called coherency matrix. The method to determine such matrix for a quasi-monochromatic light beam has been proposed for many years. In this paper, we demonstrate that the method needs to be only slightly modified to determine the matrix elements of a broadband stochastic electromagnetic light beam, if one uses the representation of statistical wave fields in the space-frequency domain. The implementation of the method is demonstrated, and the coherency matrix measurement is validated using a well-defined elliptically polarized beam.

show abstract

“…[18][19][20] Also, the approach of optimizing OCT hardware has investigated based on the use of ROC curves and AUCs for specified tasks, such as detecting the refractive index changes in multiple layers. 21,22 Here, we establish an observer for the task of diagnosing edema, which is called spatiotemporal correlation (STC) that is applied to OCT images using a rabbit airway surgical model. To the authors' knowledge, this is the first attempt to statistically quantify the differentiable characteristics of airway edema from in-vivo OCT images.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal correlation of optical coherence tomographyin-vivoimages of rabbit airway for the diagnosis of edema

et al. 2015

View full text Add to dashboard Cite

Abstract. Detection of an early stage of subglottic edema is vital for airway management and prevention of stenosis, a life-threatening condition in critically ill neonates. As an observer for the task of diagnosing edema in vivo, we investigated spatiotemporal correlation (STC) of full-range optical coherence tomography (OCT) images acquired in the rabbit airway with experimentally simulated edema. Operating the STC observer on OCT images generates STC coefficients as test statistics for the statistical decision task. Resulting from this, the receiver operating characteristic (ROC) curves for the diagnosis of airway edema with full-range OCT in-vivo images were extracted and areas under ROC curves were calculated. These statistically quantified results demonstrated the potential clinical feasibility of the STC method as a means to identify early airway edema. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

Task-based optimization and performance assessment in optical coherence imaging

Cited by 25 publications

References 10 publications

Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics

Maximum-likelihood estimation in Optical Coherence Tomography in the context of the tear film dynamics

Determination of the coherency matrix of a broadband stochastic electromagnetic light beam

Spatiotemporal correlation of optical coherence tomographyin-vivoimages of rabbit airway for the diagnosis of edema

Contact Info

Product

Resources

About