“…This suggests a powerful strategy to predict miRNA targets by computational approaches. Based on this characteristic, several laboratories have developed different computational strategies to predict miRNA targets in available genome database, and successfully identified 100s of miRNA targets for given miRNAs Enright et al, 2003;Lewis et al, 2003;Stark et al, 2003;Axton, 2004;Bonnet et al, 2004;John et al, 2004;JonesRhoades and Bartel, 2004;Kiriakidou et al, 2004;Lai, 2004;Rajewsky and Socci, 2004;Rehmsmeier et al, 2004;Wang et al, 2004;Axtell and Bartel, 2005;Bentwich, 2005;Brennecke et al, 2005;Brown and Sanseau, 2005;Burgler and Macdonald, 2005;Grun et al, 2005;Hariharan et al, 2005;Kawasaki and Taira, 2005;Krek et al, 2005;Legendre et al, 2005;Lewis et al, 2005;Li and Zhang, 2005;Nakahara et al, 2005;Robins et al, 2005;Saetrom et al, 2005;Williams et al, 2005a;Xie et al, 2005;Yoon and De Micheli, 2005;Zhang, 2005). These computer software programs include TargetScan (Lewis et al, 2003), TargetScanS (Lewis et al, 2005), miRanda (Enright et al, 2003;John et al, 2004), MovingTargets (Burgler and Macdonald, 2005), PicTar …”