2005
DOI: 10.1073/pnas.0500053102
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Targets of microRNA regulation in the Drosophila oocyte proteome

Abstract: MicroRNAs (miRNAs) are a class of small RNAs that silence gene expression. In animal cells, miRNAs bind to the 3 untranslated regions of specific mRNAs and inhibit their translation. Although some targets of a handful of miRNAs are known, the number and identities of mRNA targets in the genome are uncertain, as are the developmental functions of miRNA regulation. To identify the global range of miRNA-regulated genes during oocyte maturation of Drosophila, we compared the proteome from wild-type oocytes with th… Show more

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Cited by 74 publications
(54 citation statements)
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“…Since all miRs should be absent, the lethality of Dicer-1 deletion is hardly unexpected. In contrast, it is rather surprising that the number of proteins showing significant mis-expression was modest (at only 9%, 94 out of 1003 proteins) in the same cells (Nakahara et al 2005). Third, evidence suggests that, even for highly conserved miRNAs, their targets may not be noticeably conserved.…”
Section: Mirnas-their Paradoxical Function and Evolutionmentioning
confidence: 85%
See 2 more Smart Citations
“…Since all miRs should be absent, the lethality of Dicer-1 deletion is hardly unexpected. In contrast, it is rather surprising that the number of proteins showing significant mis-expression was modest (at only 9%, 94 out of 1003 proteins) in the same cells (Nakahara et al 2005). Third, evidence suggests that, even for highly conserved miRNAs, their targets may not be noticeably conserved.…”
Section: Mirnas-their Paradoxical Function and Evolutionmentioning
confidence: 85%
“…Thus, in animals, each miRNA may have anywhere between 20 and 200 target genes and many genes are simultaneously the targets of more than one miRNA Krek et al 2005;Lewis et al 2005;Rajewsky 2006). Not surprisingly, the down-regulation of a target gene by any particular miRNA is often modest and has been shown to be in excess of 50% only infrequently (Nakahara et al 2005;Baek et al 2008;Selbach et al 2008).…”
Section: Mirnas-their Paradoxical Function and Evolutionmentioning
confidence: 99%
See 1 more Smart Citation
“…Few target genes that are regulated by microRNAs are currently documented, but the ones identified have important roles in apoptosis, homeobox regulation, development [30,[97][98][99][100][101], cell growth and apoptosis [13,14], viral infection [15,19], and human cancer [81,[102][103][104]. This type of gene control represents a new regulatory mechanism and is predicted to affect many crucial cellular processes, including developmental programs.…”
Section: Microrna Regulation Mechanisms and Target Predictionmentioning
confidence: 99%
“…This suggests a powerful strategy to predict miRNA targets by computational approaches. Based on this characteristic, several laboratories have developed different computational strategies to predict miRNA targets in available genome database, and successfully identified 100s of miRNA targets for given miRNAs Enright et al, 2003;Lewis et al, 2003;Stark et al, 2003;Axton, 2004;Bonnet et al, 2004;John et al, 2004;JonesRhoades and Bartel, 2004;Kiriakidou et al, 2004;Lai, 2004;Rajewsky and Socci, 2004;Rehmsmeier et al, 2004;Wang et al, 2004;Axtell and Bartel, 2005;Bentwich, 2005;Brennecke et al, 2005;Brown and Sanseau, 2005;Burgler and Macdonald, 2005;Grun et al, 2005;Hariharan et al, 2005;Kawasaki and Taira, 2005;Krek et al, 2005;Legendre et al, 2005;Lewis et al, 2005;Li and Zhang, 2005;Nakahara et al, 2005;Robins et al, 2005;Saetrom et al, 2005;Williams et al, 2005a;Xie et al, 2005;Yoon and De Micheli, 2005;Zhang, 2005). These computer software programs include TargetScan (Lewis et al, 2003), TargetScanS (Lewis et al, 2005), miRanda (Enright et al, 2003;John et al, 2004), MovingTargets (Burgler and Macdonald, 2005), PicTar …”
Section: Microrna Biogenesismentioning
confidence: 99%