Targets for production of the medical radioisotopes with alpha and proton or deuteron beams

Stolarz, A.; Kowalska, J.; Jastrzȩbski, J.; Choiński, J.; Sitarz, Mateusz; Szkliniarz, Katarzyna; Trzcińska, A.; Zipper, W.

doi:10.1063/1.5035517

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…In the present studies of the reaction characteristics -as a function of projectile energy we used pellet targets designed as a homogenous mixture of the enriched target material, CaCO 3 or TiO 2, with graphite (Stolarz et al, 2018). The content of the enriched material in the mixture varied from 10 to 25% for CaCO 3 and for TiO 2 it was 20%.…”

Section: Calcium and Titanium Targets For Proton And/or Deuteron Irramentioning

confidence: 99%

Production of Sc medical radioisotopes with proton and deuteron beams

Sitarz

Szkliniarz

Jastrzȩbski

et al. 2018

Applied Radiation and Isotopes

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• proton and deuteron beams • 43,44,47 Sc radioisotopes • radioisotope production • Thick Target Yield • generated impurities level Highlights • The prospective medical scandium radioisotopes, 43 Sc, 44g Sc, 44m Sc and 47 Sc were produced using proton and deuteron beams. • Isotopically enriched and natural targets of CaCO 3 and TiO 2 were used. • The Thick Target Yields (TTY) and generated radioactive impurities were determined for a proton energy range of 28-2 MeV. • Using a proton beam and the most enriched target isotopes the highest determined TTY were about 400, 800 and 60 MBq/µAh for 43 Sc, 44g Sc and 47 Sc,respectively.

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Section: Calcium and Titanium Targets For Proton And/or Deuteron Irramentioning

confidence: 99%

Production of Sc medical radioisotopes with proton and deuteron beams

Sitarz

Szkliniarz

Jastrzȩbski

et al. 2018

Applied Radiation and Isotopes

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“…The target uses the design presented in [ 26 ]. Briefly, 85–90 mg of calcium carbonate was compacted in the form of a pill of ca.…”

Section: Methodsmentioning

confidence: 99%

Separation of 44Sc from Natural Calcium Carbonate Targets for Synthesis of 44Sc-DOTATATE

et al. 2018

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The rapid increase in applications of scandium isotopes in nuclear medicine requires new efficient production routes for these radioisotopes. Recently, irradiations of calcium in cyclotrons by α, deuteron, and proton beams have been used. Therefore, effective post-irradiation separation and preconcentration of the radioactive scandium from the calcium matrix are important to obtain the pure final product in a relatively small volume. Nobias resin was used as a sorbent for effective separation of 44Sc from calcium targets. Separation was performed at pH 3 using a column containing 10 mg of resin. Scandium was eluted with 100 μL of 2 mol L−1 HCl. Particular attention was paid to the reduction of calcium concentration, presence of metallic impurities, robustness and simple automation. 44Sc was separated with 94.9 ± 2.8% yield, with results in the range of 91.7–99.0%. Purity of the eluate was confirmed with ICP-OES determination of metallic impurities and >99% chelation efficiency with DOTATATE, followed by >36 h radiochemical stability of the complex. A wide range of optimal conditions and robustness to target variability and suspended matter facilitates the proposed method in automatic systems for scandium isotope separation and synthesis of scandium-labeled radiopharmaceuticals.

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“…The oxide targets prepared as inserts into graphite bed as described in [5] survived 45 min irradiation with 15 µA proton beam very well. There were no signs of thermal damage of the target.…”

Section: Cao (+) Achievable By Thermal Decomposition Of Caco3;mentioning

confidence: 99%

“…The thermal damages mentioned in Table 2 for calcium carbonate can be eliminated by mixing the target material with a good heat conductor e.g. graphite or aluminium as discussed in [5]. Taking into account only the level of produced activity which is proportional to the nuclei number per cm 2 as expressed in the formula The activity of the Sc radioisotopes produced during the same time of irradiation of Ca metallic target would be nearly tripled comparing to activity produced while using CaCO3 (or doubled if working with CaO).…”

Section: Cao (+) Achievable By Thermal Decomposition Of Caco3;mentioning

confidence: 99%

Calcium targets for production of the medical Sc radioisotopes in reactions with p, d or α projectiles

et al. 2020

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The scandium radioisotopes for medical application can be produced in reactions of calcium with proton, deuteron or alpha projectiles. Enriched isotopic calcium material is commercially available mainly as calcium carbonate which can be used directly for production of Sc radioisotopes or can be converted into other calcium compounds or into metallic form. The superiority of application of calcium oxide is shown throughout analysis of use of each target chemical form.

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Targets for production of the medical radioisotopes with alpha and proton or deuteron beams

Cited by 5 publications

References 8 publications

Production of Sc medical radioisotopes with proton and deuteron beams

Production of Sc medical radioisotopes with proton and deuteron beams

Separation of 44Sc from Natural Calcium Carbonate Targets for Synthesis of 44Sc-DOTATATE

Calcium targets for production of the medical Sc radioisotopes in reactions with p, d or α projectiles

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