Targetry and radiochemistry for no-carrier-added production of 109Cd

Abstract

Electrodeposition of silver on copper substrate was carried out using alkaline plating baths for production of Cadmium-109 via the nat Ag( p, n) 109 Cd nuclear reaction. The target could withstand 15 MeV proton beam currents of up to 150 µA; the 109 Cd production yield was 1.88 µCi/µA h (0.069 MBq/µA h). Cadmium-109 was separated from silver and non-isotopic impurities by ion-exchange chromatography.

Investigation of alpha particle induced reactions on natural silver in the 40–50 MeV energy range

“…The irradiations have been performed on a dedicated beam line of the K70-MeV AVF cyclotron of the RIKEN RI Beam Factory by using an Eα = 50.73±0. 3 MeV beam. The exact beam energy was determined by using the time of flight (TOF) setup [13].…”

“…111 In plays an important role in nuclear medicine as diagnostic isotope [1], but its relatively long half-life allows also industrial and research applications [2]. 109 Cd is an interesting radioisotope from the point of view of medical applications as a parent of 109m Ag [3][4][5]. Nuclear data for alpha particle induced reactions on silver have already been measured by several authors [6][7][8][9][10][11][12].…”

Radiochemistry

“…56 The nuclear reactions that lead to palladium-103, a radioisotope of use in nuclear medicine, have been comprehensively reviewed, 57 whilst more focused studies 58 have concentrated on [Rh 103 (d,2n)Pd 103 ] 59,60 and reactions leading to silver-103 (b-decay of Ag-103 leads to Pd-103). Following theoretical calculations 61 using the TAYLS code optimum conditions for production of cadmium-109 by the proton irradiation of natural silver have been determined 62,63 and details of its isolation described 64,65 . Procedures for the isolation of indium-113m from silver-110m have been reported.…”

Separation of 109Cd from silver targets by nanohematite

“…Irradiation of electroplated natural silver target on copper backing was done to induce the nat Ag( p, n) 109 Cd reaction at the cyclotron (IBA-Cyclone-30) in Agricultural, Medical and Industrial Research School with 15 MeV protons and a current of 150 µA for 1 h. The obtained yield was 70 kBq/µA h [21]. The irradiated target (0.4 g) was dissolved in 30 mL concentrated nitric acid and the solution was evaporated to dryness.…”