Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment
Esmaeel Ghasemi Gojani,
Sweta Rai,
Farzaneh Norouzkhani
et al.
Abstract:The β-cells within the pancreas play a pivotal role in insulin production and secretion, responding to fluctuations in blood glucose levels. However, factors like obesity, dietary habits, and prolonged insulin resistance can compromise β-cell function, contributing to the development of Type 2 Diabetes (T2D). A critical aspect of this dysfunction involves β-cell dedifferentiation and transdifferentiation, wherein these cells lose their specialized characteristics and adopt different identities, notably transit… Show more
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