Targeting Wee1 kinase to suppress proliferation and survival of cisplatin-resistant head and neck squamous cell carcinoma

Yang, Zhi-Zheng; Liao, Jipei; Lapidus, Rena G.; Fan, Xiaoxuan; Mehra, Ranee; Cullen, Kevin J.; Dan, Hancai

doi:10.1007/s00280-022-04410-w

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…Therefore, Wee1 suppression abrogates the G2/M checkpoint control that induces and prolongs DNA damage, ultimately leading to mitotic catastrophe and cell death [75]. Moreover, Wee1 inhibitor adavosertib shows the potential for overcoming cisplatin resistance, and the combination of adavosertib and cisplatin inhibits tumor proliferation and survival with synergy in cisplatin-resistant HNSCC by inducing DNA damage [76]. A clinical evaluation revealed that adavosertib in combination with neoadjuvant cisplatin and docetaxel was safe and well-tolerable and showed promising antitumor efficacy in patients with advanced HNSCC, implicating Wee1-targeting as a potential regimen for this disease [73].…”

Section: Taxane Resistance In Hnsccmentioning

confidence: 99%

Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma

Hsieh,

Lin,

Chang

2023

Biomedicines

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Taxanes, particularly docetaxel (DTX), has been widely used for combination therapy of head and neck squamous cell carcinoma (HNSCC). For locally advanced unresectable HNSCC, DTX combined with cisplatin and 5-fluorouracil as a revolutionary treatment revealed an advantage in the improvement of patient outcome. In addition, DTX plus immune check inhibitors (ICIs) showed low toxicity and an increased response of patients with recurrent or metastatic HNSCC (R/M HNSCC). Accumulated data indicate that taxanes not only function as antimitotics but also impair diverse oncogenic signalings, including angiogenesis, inflammatory response, ROS production, and apoptosis induction. However, despite an initial response, the development of resistance remains a major obstacle to treatment response. Taxane resistance could result from intrinsic mechanisms, such as enhanced DNA/RNA damage repair, increased drug efflux, and apoptosis inhibition, and extrinsic effects, such as angiogenesis and interactions between tumor cells and immune cells. This review provides an overview of taxanes therapy applied in different stages of HNSCC and describe the mechanisms of taxane resistance in HNSCC. Through a detailed understanding, the mechanisms of resistance may help in developing the potential therapeutic methods and the effective combination strategies to overcome drug resistance.

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Section: Taxane Resistance In Hnsccmentioning

confidence: 99%

Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma

Hsieh,

Lin,

Chang

2023

Biomedicines

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Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma

Hsieh,

Lin,

Chang

2023

Preprint

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Taxanes, particularly docetaxel (DTX), has been widely used for combination therapy of head and neck squamous cell carcinoma (HNSCC). For locally advanced unresectable HNSCC, DTX combined with cisplatin and 5-fluorouracil as a revolutionary treatment revealed an advantage in improvement of patient outcome. In addition. DTX plus immune check inhibitors (ICIs) showed low toxicity and increased response of patients with recurrent or metastatic HNSCC (R/M HNSCC). Accumulating data indicate that taxanes not only function as antimitotics but also impair diverse oncogenic signalings including angiogenesis, inflammatory response, ROS production, and apoptosis induction. However, despite an initial response, development of resistance remains a major obstacle to treatment response. Taxane resistance could result from intrinsic mechanisms such as enhanced DNA/RNA damage repair, increased drug efflux, and apoptosis inhibition, and extrinsic effects such as angiogenesis and interactions between tumor cells and immune cells. This review provides an overview of taxanes therapy applied in different stages of HNSCC and describe the mechanisms of taxane resistance in HNSCC. Through a detailed understanding the mechanisms of resistance may help developing the potential therapeutic methods and the effective combination strategies to overcome drug resistance.

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Targeting DNA damage response as a potential therapeutic strategy for head and neck squamous cell carcinoma

Lei

He²,

Jiang³

et al. 2022

Front. Oncol.

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Cells experience both endogenous and exogenous DNA damage daily. To maintain genome integrity and suppress tumorigenesis, individuals have evolutionarily acquired a series of repair functions, termed DNA damage response (DDR), to repair DNA damage and ensure the accurate transmission of genetic information. Defects in DNA damage repair pathways may lead to various diseases, including tumors. Accumulating evidence suggests that alterations in DDR-related genes, such as somatic or germline mutations, single nucleotide polymorphisms (SNPs), and promoter methylation, are closely related to the occurrence, development, and treatment of head and neck squamous cell carcinoma (HNSCC). Despite recent advances in surgery combined with radiotherapy, chemotherapy, or immunotherapy, there has been no substantial improvement in the survival rate of patients with HNSCC. Therefore, targeting DNA repair pathways may be a promising treatment for HNSCC. In this review, we summarized the sources of DNA damage and DNA damage repair pathways. Further, the role of DNA damage repair pathways in the development of HNSCC and the application of small molecule inhibitors targeting these pathways in the treatment of HNSCC were focused.

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Targeting Wee1 kinase to suppress proliferation and survival of cisplatin-resistant head and neck squamous cell carcinoma

Cited by 3 publications

References 47 publications

Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma

Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma

Taxanes in the Treatment of Head and Neck Squamous Cell Carcinoma

Targeting DNA damage response as a potential therapeutic strategy for head and neck squamous cell carcinoma

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