Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapy

Yu, Mengchao; Lun, Jie; Zhang, Hongwei; Wang, Lei; Zhang, Gang; Zhang, Haisheng; Fang, Jing

doi:10.1093/abbs/gmab131

Cited by 10 publications

(5 citation statements)

References 109 publications

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“…Furthermore, a positive association between ITGAV expression and chemotherapeutic drug sensitivity was exhibted, which has guiding implications in clinical practice. Alvaro et al, have found that in breast cancer, breast epithelial cells detached from ECM can synergistically induce antioxidant response and autophagy through activation of PERK to reduce the level of ROS to delay anoikis [ [37] , [38] , [39] ]. It has also been demonstrated that OGT/O-GlcNAcylation has a high level in many cancers and is closely related to poor survival, unanchored growth, migration, and invasion of lung cancer [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

The multi-omics analysis identifies a novel cuproptosis-anoikis-related gene signature in prognosis and immune infiltration characterization of lung adenocarcinoma

Jiang

Song

Wang

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

The multi-omics analysis identifies a novel cuproptosis-anoikis-related gene signature in prognosis and immune infiltration characterization of lung adenocarcinoma

Jiang

Song

Wang

et al. 2023

Heliyon

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“…One problem with the existing anticancer drugs is that a particular drug shows different sensitivities in different individuals. Targeting UPR branches is a promising way to enhance the efficacy of chemotherapy for cancers [ 40 ]. Considering the above problem, we performed a UPR-related IC50 analysis to explore sensitivities and help HNSCC patients obtain personalized medication regimens.…”

Section: Discussionmentioning

confidence: 99%

Construction and Validation of a UPR-Associated Gene Prognostic Model for Head and Neck Squamous Cell Carcinoma

Wang

Chen

Xie

et al. 2022

BioMed Research International

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Our study is aimed at constructing and validating a UPR-associated gene signature to predict HNSCC prognosis. We obtained 544 samples of RNA sequencing data and clinical characteristics from TCGA database and randomly grouped the samples into training and testing cohorts (1 : 1 ratio). After identifying 14 UPR-associated genes with LASSO and univariate Cox regression analysis, HNSCC samples were categorized into low-risk (LR) and high-risk (HR) subgroups depending on the risk score. Our analyses indicated that low-risk patients had a much better prognosis in the training and testing cohorts. To predict the HNSCC prognosis with the 14 UPR-associated gene signatures, we incorporated the UPR gene risk score, N stage, M stage, and age into a nomogram model. We further explored the sensitivity to anticancer drugs by using the IC50 analysis in two subgroups from the Cancer Genome Project database. The outcomes showed that the AKT inhibitor III and sorafenib were sensitive anticancer drugs in HR and LR patients, respectively. The immune cell infiltration analysis and GSEA provided strong evidence for elucidating the molecular mechanisms of UPR-associated genes affecting HNSCC. In conclusion, the UPR-associated gene risk score, N stage, M stage, and age can serve as a robust model for predicting prognosis and can improve decision-making at the individual patient level.

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“…Additionally, OA can destroy the homeostasis of the endoplasmic reticulum (ER), but it can be rebuilt by the unfolded protein response (UPR), which is mainly mediated by protein kinase RNA-like ER kinase (PERK), inositol-requiring enzyme 1α (IRE-1α) and activating transcription factor 6 (ATF6) ( Figure 5 ) [ 125 ‒ 127 ] . Among these pathways, both PERK and IRE-1α can regulate actin cytoskeleton dynamics through the binding with filamin A, and filamin A regulates the action of actin filaments and cytoskeleton dynamics, facilitating cell migration [128] .…”

Section: The Mechanism Of Mgf In Chondrocytes and Cartilage Defectsmentioning

confidence: 99%

The role of mechano growth factor in chondrocytes and cartilage defects: a concise review

Liu¹,

Duan²,

Zhang³

et al. 2023

ABBS

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Mechano growth factor (MGF), an isoform of insulin-like growth factor 1 (IGF-1), is recognized as a typical mechanically sensitive growth factor and has been shown to play an indispensable role in the skeletal system. In the joint cavity, MGF is highly expressed in chondrocytes, especially in the damaged cartilage tissue caused by trauma or degenerative diseases such as osteoarthritis (OA). Cartilage is an extremely important component of joints because it functions as a shock absorber and load distributer at the weight-bearing interfaces in the joint cavity, but it can hardly be repaired once injured due to its lack of blood vessels, lymphatic vessels, and nerves. MGF has been proven to play an important role in chondrocyte behaviors, including cell proliferation, migration, differentiation, inflammatory reactions and apoptosis, in and around the injury site. Moreover, under the normalized mechanical microenvironment in the joint cavity, MGF can sense and respond to mechanical stimuli, regulate chondrocyte activity, and maintain the homeostasis of cartilage tissue. Recent reports continue to explain its effects on various cell types and sport-related tissues, but its role in cartilage development, homeostasis and disease occurrence is still controversial, and its internal biological mechanism is still elusive. In this review, we summarize recent discoveries on the role of MGF in chondrocytes and cartilage defects, including tissue repair at the macroscopic level and chondrocyte activities at the microcosmic level, and discuss the current state of research and potential gaps in knowledge.

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Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapy

Cited by 10 publications

References 109 publications

The multi-omics analysis identifies a novel cuproptosis-anoikis-related gene signature in prognosis and immune infiltration characterization of lung adenocarcinoma

The multi-omics analysis identifies a novel cuproptosis-anoikis-related gene signature in prognosis and immune infiltration characterization of lung adenocarcinoma

Construction and Validation of a UPR-Associated Gene Prognostic Model for Head and Neck Squamous Cell Carcinoma

The role of mechano growth factor in chondrocytes and cartilage defects: a concise review

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