Targeting Ultrasmall Gold Nanoparticles with cRGD Peptide Increases the Uptake and Efficacy of Cytotoxic Payload

Perrins, Richard D.; McCarthy, L. V.; Robinson, Angela Byun; Spry, Kelly L.; Cognet, Valentin; Ferreira, Avelino; Porter, John; Garcia, Cristina Espinosa; Rodríguez, Miguel Ángel; López, Diana M.; Perera, Ibon; Conlon, Kelly; Barrientos, África G.; Coulter, Tom; Pace, Alessandro; Hale, Sarah; Ferrari, Enrico; Bachrati, Csanád Z.

doi:10.3390/nano12224013

Cited by 6 publications

(5 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taken together, our findings suggest that Bm-GNPs merit further scientific exploration at molecular and preclinical levels. To enhance their target specificity, conjugating them with target-specific antibodies 60 or peptides 61 can be explored.…”

Section: Discussionmentioning

confidence: 99%

Induction of autophagy-dependent and caspase- and microtubule-acetylation-independent cell death by phytochemical-stabilized gold nanopolygons in colorectal adenocarcinoma cells

Meher,

Radha,

Lopus

2024

Nanoscale

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Induction of autophagy-dependent and caspase- and microtubule-acetylation-independent cell death by phytochemical-stabilized gold nanopolygons in colorectal adenocarcinoma cells

Meher,

Radha,

Lopus

2024

Nanoscale

View full text Add to dashboard Cite

show abstract

“…Another common decoration method is via thiol-containing biomolecules which can form covalent bonds with AuNPs via their thiol groups [ 47 ]. This method is highly specific and efficient and results in stable conjugates.…”

Section: Synthesis and Bioconjugation Of Gold Nanoparticlesmentioning

confidence: 99%

Gold Nanoparticle-Based Plasmonic Biosensors

Ferrari

2023

Biosensors

Self Cite

View full text Add to dashboard Cite

One of the emerging technologies in molecular diagnostics of the last two decades is the use of gold nanoparticles (AuNPs) for biosensors. AuNPs can be functionalized with various biomolecules, such as nucleic acids or antibodies, to recognize and bind to specific targets. AuNPs present unique optical properties, such as their distinctive plasmonic band, which confers a bright-red color to AuNP solutions, and their extremely high extinction coefficient, which makes AuNPs detectable by the naked eye even at low concentrations. Ingenious molecular mechanisms triggered by the presence of a target analyte can change the colloidal status of AuNPs from dispersed to aggregated, with a subsequent visible change in color of the solution due to the loss of the characteristic plasmonic band. This review describes how the optical properties of AuNPs have been exploited for the design of plasmonic biosensors that only require the simple mixing of reagents combined with a visual readout and focuses on the molecular mechanisms involved. This review illustrates selected examples of AuNP-based plasmonic biosensors and promising approaches for the point-of-care testing of various analytes, spanning from the viral RNA of SARS-CoV-2 to the molecules that give distinctive flavor and color to aged whisky.

show abstract

“…More recently, D. Perrins et al functionalized ultrasmall gold nanoparticles with the cRGD peptide, which binds to the α V β 3 integrin receptor, which is overexpressed in many tumors such as melanoma [ 76 , 206 ]. Moreover, cRGD-ultrasmall GNPs loaded with the maytansinoid drug (DM1), a tubulin polymerization inhibitor, showed increased cytotoxicity selectively on cells that expressed the α V β 3 integrin [ 207 , 208 ].…”

Section: Peptide-based Targeting Strategies For Drug Delivery Systemsmentioning

confidence: 99%

Targeting Peptides: The New Generation of Targeted Drug Delivery Systems

et al. 2023

View full text Add to dashboard Cite

Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and antibodies. They are particularly efficient in terms of production and stability in physiological environments; in recent years, they have been increasingly studied as targeting agents for several diseases, from tumors to central nervous system disorders, also thanks to the ability of some of them to cross the blood–brain barrier. In this review, we will describe the techniques employed for their experimental and in silico design, as well as their possible applications. We will also discuss advancements in their formulation and chemical modifications that make them even more stable and effective. Finally, we will discuss how their use could effectively help to overcome various physiological problems and improve existing treatments.

show abstract

Targeting Ultrasmall Gold Nanoparticles with cRGD Peptide Increases the Uptake and Efficacy of Cytotoxic Payload

Cited by 6 publications

References 87 publications

Induction of autophagy-dependent and caspase- and microtubule-acetylation-independent cell death by phytochemical-stabilized gold nanopolygons in colorectal adenocarcinoma cells

Induction of autophagy-dependent and caspase- and microtubule-acetylation-independent cell death by phytochemical-stabilized gold nanopolygons in colorectal adenocarcinoma cells

Gold Nanoparticle-Based Plasmonic Biosensors

Targeting Peptides: The New Generation of Targeted Drug Delivery Systems

Contact Info

Product

Resources

About