Targeting type 2 inflammation in bullous pemphigoid: current and emerging therapeutic approaches
Wu Han Toh,
Hua-En Lee,
Chun-Bing Chen
Abstract:Bullous pemphigoid (BP) is one of the most common autoimmune bullous diseases and mainly affects an elderly population with multi-morbidity. Due to the frailty of many BP patients, existing treatment options are limited. The blisters associated with BP result from IgG and IgE autoantibodies binding to the central components of hemidesmosome, BP180, and BP230, stimulating a destructive inflammatory process. The known characteristic features of BP, such as intense pruritus, urticarial prodrome, peripheral eosino… Show more
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