Targeting thiamine-dependent enzymes for metabolic therapies in oral squamous cell carcinoma?

Grimm, Martin; Calgéer, B.; Teriete, Peter; Biegner, Thorsten; Munz, Adelheid; Reinert, Siegmar

doi:10.1007/s12094-015-1352-5

Cited by 12 publications

(8 citation statements)

References 55 publications

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“…The underlying mechanism of the relationship between vitamin K intake and CIN risk needs to be further explored. Some studies have found that vitamin B1 has anticancer effects in myeloproliferative neoplasms [62] and oral SCC [63]. Our study results showed that dietary vitamin B1 intake was signi cantly associated with CIN1 risk.…”

Section: Folatesupporting

confidence: 60%

Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

Wang

Yang

et al. 2020

Preprint

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Background: Dietary nutrient intake plays a significant role in carcinogenesis. Few studies have investigated the association between dietary nutrient intake and cervical intraepithelial neoplasia (CIN) risk in China. Methods: Data on 2,304 women from an ongoing cohort comprising 40,000 women from China in 2014 were included. We randomly selected 218 out of 2304 people as subjects during 2019. All participants were surveyed through in-person interviews, physical examinations, and laboratory tests. Clinical data were obtained from physical examinations and laboratory tests. Dietary intakes were assessed using a semiquantitative food frequency questionnaire. Nutrition intakes from 26 food sources were calculated using a comprehensive validated database. Descriptive statistics were used to describe the frequency and proportion, and mean and standard deviation of the demographic characteristics. Characteristics were examined for significant differences, and Pearson chi-square tests were used for categoric variables. Logistic regression was used to obtain odds ratios (ORs) and confidence intervals (CIs) for CIN risk in each nutritional ingredient quartile relative to that in the highest quartile. Results: The food frequency questionnaire exhibited acceptable reproducibility and reasonable validity in assessing nutrient intakes among these women. After adjusting for multiple confounders, several dietary nutrients showed significant associations with CIN2+ risk. Low dietary folate intake was associated with the risk of CIN2+ (first versus fourth quartile: OR=1.55, 95% CI: 1.03-2.33). Similar results were also observed for vitamin B6 (OR=1.63, 95% CI: 1.08-2.46), vitamin C (OR=1.59, 95% CI: 1.05-2.42), niacin (OR=1.65, 95% CI: 1.08-2.51), and vitamin K (second versus fourth quartile: OR=1.60, 95% CI: 1.05-2.44).Conclusions: Low folate; vitamin B6, C, and K; and niacin intakes were associated with CIN2+ risk. Nutrients may influence the development of higher grade CIN and cervical cancer.Trial registration: The study was registered in the Chinese Clinical Trial Register (ChiCTR-ROC-15006479) (http://www.chictr.org.cn).

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Section: Folatesupporting

confidence: 60%

Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

Wang

Yang

et al. 2020

Preprint

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“…OSCCs were stratified in a young (<45 years (16)) female (n=7, Table 1) study cohort and older patients (n=46, Table 2) (18). In the young female study cohort three patients (n=3/7) developed OSCC during or shortly after pregnancy.…”

Section: Methodsmentioning

confidence: 99%

Estrogen and Progesterone hormone receptor expression in oral cavity cancer

Grimm

Biegner²,

Teriete³

et al. 2016

Med Oral

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BackgroundRecent studies have shown an increase in the incidence of oral squamous cell carcinoma (OSCC) in younger patients. The hypothesis that tumors could be hormonally induced during pregnancy or in young female patients without the well-known risk factors alcohol or tobacco abuse seems to be plausible.Material and MethodsEstrogen Receptor alpha (ERα) and Progesterone Receptor (PR) expression were analyzed in normal oral mucosa (n=5), oral precursor lesions (simple hyperplasia, n=11; squamous intraepithelial neoplasia, SIN I-III, n=35), and OSCC specimen. OSCCs were stratified in a young female (n=7) study cohort and older patients (n=46). In the young female study cohort three patients (n=3/7) developed OSCC during or shortly after pregnancy. Breast cancer tissues were used as positive control for ERα and PR expression.ResultsERα expression was found in four oral precursor lesions (squamous intraepithelial neoplasia, SIN I-III, n=4/35, 11%) and in five OSCC specimen (n=5/46, 11%). The five ERα positive OSCC samples were older male patients. All patients within the young female study cohort were negatively stained for both ERα and PR.ConclusionsER expression could be regarded as a seldom risk factor for OSCC. PR expression seems to be not relevant for the development of OSCC. Key words:Oral squamous cell carcinoma, estrogen receptor, progesterone receptor, hormone receptor.

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“…Both LDHA overexpression and LDHB overexpression have been associated with poor survival in OSCC indicating that LDH expression is an general unfavorable factor for OSCC. As currently discussed and demonstrated by others tumors with intensively upregulated aerobic and anaerobic metabolic potential could occur due to genetic events that allow a switch on the entire cellular metabolism with a molecular ‘survival of the fittest’ scenario. In part, a nuclear staining pattern was found for LDHA and LDHB expression in IHC as it is well known that LDH resides in both the cytoplasm and nuclei .…”

Section: Discussionmentioning

confidence: 90%

Monitoring a ‘metabolic shift’ after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase

Grimm¹,

Krimmel²,

Hoefert³

et al. 2015

J Oral Pathology Medicine

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Targeting thiamine-dependent enzymes for metabolic therapies in oral squamous cell carcinoma?

Abstract: This is the first study showing increased expression of TDEs in OSCC. Metabolic targeting of TDEs (including TKTs) by antagonistic compounds like oxythiamine or oxybenfothiamine may be a useful strategy to sensitize cancer cells to common OSCC cancer therapies.

Cited by 12 publications

References 55 publications

Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

Dietary nutrient intake related to higher grade cervical intraepithelial neoplasia risk: A Chinese population-based study

Estrogen and Progesterone hormone receptor expression in oral cavity cancer

Monitoring a ‘metabolic shift’ after surgical resection of oral squamous cell carcinomas by serum lactate dehydrogenase

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