Targeting the tumor promoting effects of adenosine in chronic lymphocytic leukemia

Cai, Yin; Li, Feng; Wang, Xin

doi:10.1016/j.critrevonc.2018.03.022

Cited by 10 publications

(7 citation statements)

References 98 publications

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“…Hypoxia, acute and chronic inflammation, platelet aggregation and anticancer therapies induce tumor cells death and metabolic changes, leading to the increased concentrations of eATP and ADO in tumor microenvironment (TME) [5]. The accumulation of extracellular nucleotides and nucleosides is negligible in healthy tissues, except in highly secluded compartments, such as synaptic clefts and the interstitium of exercising muscle [6,7].…”

Section: Introductionmentioning

confidence: 99%

The yin and yang functions of extracellular ATP and adenosine in tumor immunity

Cai

Zhu

et al. 2020

Cancer Cell Int

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Extracellular adenosine triphosphate (eATP) and its main metabolite adenosine (ADO) constitute an intrinsic part of immunological network in tumor immunity. The concentrations of eATP and ADO in tumor microenvironment (TME) are controlled by ectonucleotidases, such as CD39 and CD73, the major ecto-enzymes expressed on immune cells, endothelial cells and cancer cells. Once accumulated in TME, eATP boosts antitumor immune responses, while ADO attenuates immunity against tumors. eATP and ADO, like yin and yang, represent two opposite aspects from immuneactivating to immune-suppressive signals. Here we reviewed the functions of eATP and ADO in tumor immunity and attempt to block eATP hydrolysis, ADO formation and their contradictory effects in tumor models, allowing the induction of effective anti-tumor immune responses in TME. These attempts documented that therapeutic approaches targeting eATP/ADO metabolism and function may be effective methods in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

The yin and yang functions of extracellular ATP and adenosine in tumor immunity

Cai

Zhu

et al. 2020

Cancer Cell Int

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“…Considerable research has been conducted in the last few years on the diverse roles and associated mechanisms of extracellular adenosine signaling. Extracellular adenosine has a wide variety of effects on cell cycle control, immunoregulation, and cytokine regulation via both direct and indirect processes, eventually contributing to the development of malignant diseases [ 122 ]. Adenosine has been detected in urinary EVs from prostate cancer patients [ 59 ].…”

Section: Functional Role Of Ev-transferred Metabolites In Cancermentioning

confidence: 99%

The role of the metabolite cargo of extracellular vesicles in tumor progression

Harmati

Bukva

Böröczky

et al. 2021

Cancer Metastasis Rev

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Metabolomic reprogramming in tumor and stroma cells is a hallmark of cancer but understanding its effects on the metabolite composition and function of tumor-derived extracellular vesicles (EVs) is still in its infancy. EVs are membrane-bound sacs with a complex molecular composition secreted by all living cells. They are key mediators of intercellular communication both in normal and pathological conditions and play a crucial role in tumor development. Although lipids are major components of EVs, most of the EV cargo studies have targeted proteins and nucleic acids. The potential of the EV metabolome as a source for biomarker discovery has gained recognition recently, but knowledge on the biological activity of tumor EV metabolites still remains limited. Therefore, we aimed (i) to compile the list of metabolites identified in tumor EVs isolated from either clinical specimens or in vitro samples and (ii) describe their role in tumor progression through literature search and pathway analysis.

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“…In humans, Ado is a homeostatic regulator and a "danger signal" for cells and organs, since it is expressed during trauma or stress (100,101). The therapeutic potential of Ado is well documented elsewhere (100)(101)(102). Ado is protective against several pathologies including inflammation and various forms of neuronal hyperexcitability and/or toxicity including hypoxia, seizures, and chronic pain (101).…”

Section: Inflammationmentioning

confidence: 99%

Tick Salivary Compounds for Targeted Immunomodulatory Therapy

et al. 2020

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Immunodeficiency disorders and autoimmune diseases are common, but a lack of effective targeted drugs and the side-effects of existing drugs have stimulated interest in finding therapeutic alternatives. Naturally derived substances are a recognized source of novel drugs, and tick saliva is increasingly recognized as a rich source of bioactive molecules with specific functions. Ticks use their saliva to overcome the innate and adaptive host immune systems. Their saliva is a rich cocktail of molecules including proteins, peptides, lipid derivatives, and recently discovered non-coding RNAs that inhibit or modulate vertebrate immune reactions. A number of tick saliva and/or salivary gland molecules have been characterized and shown to be promising candidates for drug development for vertebrate immune diseases. However, further validation of these molecules at the molecular, cellular, and organism levels is now required to progress lead candidates to clinical testing. In this paper, we review the data on the immunopharmacological aspects of tick salivary compounds characterized in vitro and/or in vivo and present recent findings on non-coding RNAs that might be exploitable as immunomodulatory therapies.

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Targeting the tumor promoting effects of adenosine in chronic lymphocytic leukemia

Cited by 10 publications

References 98 publications

The yin and yang functions of extracellular ATP and adenosine in tumor immunity

The yin and yang functions of extracellular ATP and adenosine in tumor immunity

The role of the metabolite cargo of extracellular vesicles in tumor progression

Tick Salivary Compounds for Targeted Immunomodulatory Therapy

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