Targeting the Lung: Challenges in Gene Therapy for Cystic Fibrosis

Cell-based therapy for idiopathic pulmonary fibrosis

“…This has been proposed by developing genetically modified stem cells using viral vectors targeting IPF disease (81). Lung fibrosis such as cystic fibrosis, is indeed an ideal gene therapy target, compared to other lung diseases for several reasons, including the ease of access to the lung, and both CFTR gene cloning and characterization (143). However, this kind of therapy still have several barriers and challenges (143).…”