Targeting the Hippo pathway to prevent radioresistance brain metastases from the lung (Review)
Jasmine Taylor,
Fatéméh Dubois,
Emmanuel Bergot
et al.
Abstract:The prognosis for patients with non-small cell lung cancer (NSCLC), a cancer type which represents 85% of all lung cancers, is poor with a 5-year survival rate of 19%, mainly because NSCLC is diagnosed at an advanced and metastatic stage. Despite recent therapeutic advancements, ~50% of patients with NSCLC will develop brain metastases (BMs). Either surgical BM treatment alone for symptomatic patients and patients with single cerebral metastases, or in combination with stereotactic radiotherapy (RT) for patien… Show more
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