Targeting the gut–lung microbiota axis by means of a high-fibre diet and probiotics may have anti-inflammatory effects in COVID-19 infection

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 is a 2019 novel coronavirus, which only in the European area has led to more than 300,000 cases with at least 21,000 deaths. This manuscript aims to speculate that the manipulation of the microbial patterns through the use of probiotics and dietary fibers consumption may contribute to reduce inflammation and strengthen the immune system response in COVID-19 infection. The reviews of this paper are available via the supplemental material section.

Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome

“…The use of prebiotics and probiotics to regulate the balance of the intestinal flora could be an effective treatment to reduce the risk of bacterial and viral infections. 143 It would also be useful to investigate the effect of high-fiber diets and/or probiotics on the outcome of SARS-CoV-2 infection. Design treatments for COVID-19 would be based on the administration of both probiotics and prebiotics, or nutrients that would replace the absent bacteria, thus preventing the risk of systemi infection.…”

Potential beneficial role of probiotics on the outcome of COVID-19 patients: An evolving perspective

“…This alteration modifies the composition of the intestinal microbiota both qualitatively and quantitatively. In turn, this influences the gut/pulmonary crosstalk [ 14 , 18 , [21] , [22] , [23] , [24] ].…”

“…In fact, one of the main pathogenic mechanisms causing pulmonary acute damage is the “cytokine storm”. IL-6 is one of the main pro-inflammatory markers in this sense [ 9 , 18 , 24 , 25 ].…”

SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role

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