Targeting the Extracellular Matrix

Giavazzi, Raffaella; Taraboletti, Giulia

doi:10.1002/0470025077.chap94

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Dietary consumption of anthocyanin has been shown to improve overall antioxidant defense status of human plasma [12]. On one hand, the search is on for specific medical drugs that would efficiently limit angiogenesis [13,14]. On the other hand, diet‐based approaches to limit angiogenesis are being actively explored [7,8,15–20].…”

Section: Introductionmentioning

confidence: 99%

Anti‐angiogenic property of edible berry in a model of hemangioma

et al. 2003

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Hemangiomas represent a powerful model to study in vivo angiogenesis. Monocyte chemotactic protein 1 (MCP-1) is known to be responsible for recruiting macrophages to sites of infection or in£ammation and facilitate angiogenesis. Recently we have demonstrated that edible berry extracts potently suppress inducible vascular endothelial growth factor expression and in vitro angiogenesis. Comparative analysis of several berry extracts led to the observation that wild blueberry and a berry mix were most e¡ective. Our goal was to follow up on our ¢ndings with wild blueberry and the berry mix (OptiBerry). The present work rests on our current ¢nding that these two berry powders signi¢cantly inhibit inducible MCP-1 expression in endothelioma cells. Therefore, we sought to examine the effects of wild blueberry and berry mix in an in vivo model of experimental angiogenesis. Reporter studies showed that the berry powders signi¢cantly inhibited basal MCP-1 transcription and inducible nuclear factor U UB transcription. Endothelioma cells pre-treated with berry powders showed diminished ability to form hemangioma. Histological analysis demonstrated markedly decreased in¢ltration of macrophages in hemangioma of treated mice compared to placebo-treated controls. The current results provide the ¢rst in vivo evidence substantiating the antiangiogenic property of edible berries. ß

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Section: Introductionmentioning

confidence: 99%