Targeting the epigenome with advanced delivery strategies for epigenetic modulators
Sonia Guha,
Yogeswaran Jagadeesan,
Murali Monohar Pandey
et al.
Abstract:Epigenetics mechanisms play a significant role in human diseases by altering DNA methylation status, chromatin structure, and/or modifying histone proteins. By modulating the epigenetic status, the expression of genes can be regulated without any change in the DNA sequence itself. Epigenetic drugs exhibit promising therapeutic efficacy against several epigenetically originated diseases including several cancers, neurodegenerative diseases, metabolic disorders, cardiovascular disorders, and so forth. Currently,… Show more
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