Targeting the deubiquitinase USP2 for malignant tumor therapy (Review)
Shilong Zhang,
Yi Guo,
Shenjie Zhang
et al.
Abstract:The ubiquitin-proteasome system is a major degradation pathway for >80% of proteins in vivo. Deubiquitylases, which remove ubiquitinated tags to stabilize substrate proteins, are important components involved in regulating the degradation of ubiquitinated proteins. In addition, they serve multiple roles in tumor development by participating in physiological processes such as protein metabolism, cell cycle regulation, DNA damage repair and gene transcription. The present review systematically summarized the rol… Show more
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