Targeting the Complex Protein Network of MYCN-amplified Anaplastic Ependymoma: A Case Report

Abstract

An especially aggressive and poor prognosis form of adultonset anaplastic ependymoma is driven by N-myc protooncogene (MYCN) amplification [2,3]. The MYCN gene codes for the protein N-Myc, an E-box binding, basic helix leucine zipper (bHLH-LZ) transcription factor which orchestrates a network of signaling pathway aberrations characterized