Targeting the [CL/cyt c] complex to protect electron transport and prevent ROS formation prevents mitochondrial IR injury without ROS scavenging (LB169)
Abstract:SS‐31 (D‐Arg‐dimethylTyr‐Lys‐Phe‐NH2) is a ROS‐scavenging cardiolipin‐targeting tetrapeptide which is known to protect against oxidative stress‐induced ischemia‐reperfusion (IR) injury. The interaction of CL with cytochrome c (cyt c) is necessary for electron carrier function of cyt c but can also lead to a [CL/cyt c] complex formation, which prevents electron transfer and promotes superoxide and hydrogen peroxide generation. SS‐31 was shown to protect the carrier function of cyt c while preventing oxidative s… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.