Abstract:Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β and α2δ subunits. The β subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the poreforming α subunit of CaV. We targeted the high-affinity protein-protein interface of CaVβ's pocket within the CaVα-subunit. Structure-based virtual screening of 50,000 small molecule library docked to the β -subunit… Show more
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