Targeting the androgenic pathway in elderly patients with castration-resistant prostate cancer

Roviello, Giandomenico; Cappelletti, Maria Rosa; Zanotti, Laura; Gobbi, Angela; Senti, Chiara; Bottini, Alberto; Ravelli, Andrea; Bonetta, Alberto; Paganini, Giovanni; Generali, Daniele

doi:10.1097/md.0000000000004636

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…Adverse events (AEs) related to mineralocorticoid excess and liver function abnormalities were more frequent with abiraterone, but mostly mild. In a subset analysis, Roviello et al showed that abiraterone was equally effective in adults older than 75 years of age when compared to their younger counterparts [49]. Neuropsychological consequences were assessed by Harland et al; abiraterone delayed median time to emotional wellbeing deterioration by more than 6 months when compared to prednisone [50].…”

Section: Abiraterone Acetate Prior To Docetaxelmentioning

confidence: 99%

Contemporary Systemic Therapy Intensification for Prostate Cancer: A Review for General Practitioners in Oncology

Batra,

Glick,

Valdes

2024

Current Oncology

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Prostate cancer accounts for a significant proportion of cancer diagnoses in Canadian men. Over the past decade, the therapeutic landscape for the management of metastatic prostate cancer has undergone rapid changes. Novel strategies use hormonal agents, chemotherapy, homologous recombination repair inhibitors, and radioligand therapy or combination strategies in addition to androgen deprivation therapy. In this review, we summarize the available data addressing key therapeutic areas along the disease continuum and focus on practical aspects for general practitioners in oncology managing patients with metastatic prostate cancer.

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Section: Abiraterone Acetate Prior To Docetaxelmentioning

confidence: 99%

Contemporary Systemic Therapy Intensification for Prostate Cancer: A Review for General Practitioners in Oncology

Batra,

Glick,

Valdes

2024

Current Oncology

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“…Part III: Urine culture& microbial resistance: This part was developed by the researcher based on relevant literature (Roviello et al, 2017), to assess type of microorganism as well as type of antibiotic sensitive to it.…”

Section: Toolsmentioning

confidence: 99%

Effect of an Instructional Module on Acute Side Effects of Intensity Modulated Radiotherapy for Patients with Cancer Prostate

Weheida,

Ahmed,

Abdo

et al. 2023

Alexandria Scientific Nursing Journal

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Background: Over the past few decades, there have been significant advances in the delivery of radiotherapy. These include developments in treatment planning systems and linear accelerator delivery capabilities, which reduce the risk of toxicity and morbidity as intensity modulated radiotherapy (IMRT). However have certain negative acute side effects as urinary tract infection (urinary urgency, frequency and dysuria), diarrhea, severe pain in anorectal area, hemorrhoids, radiation dermatitis and fatigue. Objective: To evaluate the effect of an instructional module on acute side effects of intensity modulated radiotherapy for patients with cancer prostate. Settings: The study was carried out in the radiotherapy unit at Ayadi Almostakble Charity Hospital, Egypt. Subjects: Random sample of 90 adult patients, who were divided in to two equal groups. Study group received an instructional module for acute side effects& routine hospital care, while control group received only routine hospital care. Tools: three tools were used. Tool one: "patients with cancer prostate; sociodemographic& clinical data ". Tool two: "patient's knowledge regarding cancer prostate& intensity modulated radiotherapy structured interview schedule" and tool three" cancer prostate: acute radiotherapy side effects& action taken: structured interview schedule". Results: The study showed that there was a significant improvement in side effects in the study group more than in the control group (P=0.000*). Furthermore, majority of the study groups exhibited satisfactory level of practice to reduce these side effects (P= <0.001*). Conclusion: The patients with prostatic cancer received educational program had significant improvement of knowledge and self-care practice than the control group. Recommendations: In service training program should be carried out for nurses working in radiotherapy department, about acute radiotherapy side effects and its management.

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“…The androgen receptor (AR) plays a key role in the tumorigenesis of prostate cancer and is thus an effective therapeutic target in prostate cancer [160,161]. Antiandrogenic drugs such as flutamide and enzalutamide can control the progression of prostate cancer via maximal androgen blockade [162,163]. However, the development of castration resistance is inevitable.…”

Section: Endocrine Drugsmentioning

confidence: 99%

CircRNAs in anticancer drug resistance: recent advances and future potential

Wang

Jiang

et al. 2020

Mol Cancer

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CircRNAs are a novel class of RNA molecules with a unique closed continuous loop structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue specificity, and can play a biological regulatory role at various levels, such as transcriptional and posttranscriptional levels. Numerous studies have indicated that circRNAs serve a crucial purpose in cancer biology. CircRNAs regulate tumor behavioral phenotypes such as proliferation and migration through various molecular mechanisms, such as miRNA sponging, transcriptional regulation, and protein interaction. Recently, several reports have demonstrated that they are also deeply involved in resistance to anticancer drugs, from traditional chemotherapeutic drugs to targeted and immunotherapeutic drugs. This review is the first to summarize the latest research on circRNAs in anticancer drug resistance based on drug classification and to discuss their potential clinical applications.

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Targeting the androgenic pathway in elderly patients with castration-resistant prostate cancer

Abstract: Supplemental Digital Content is available in the text

Cited by 7 publications

References 39 publications

Contemporary Systemic Therapy Intensification for Prostate Cancer: A Review for General Practitioners in Oncology

Contemporary Systemic Therapy Intensification for Prostate Cancer: A Review for General Practitioners in Oncology

Effect of an Instructional Module on Acute Side Effects of Intensity Modulated Radiotherapy for Patients with Cancer Prostate

CircRNAs in anticancer drug resistance: recent advances and future potential

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