Targeting the altered duodenal microenvironment in functional dyspepsia

Ceulemans, Michael; Wauters, Lucas; Vanuytsel, Tim

doi:10.1016/j.coph.2023.102363

Cited by 3 publications

(2 citation statements)

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“…Currently, treatment options for FD include dietary modifications, probiotics, antibiotics, acid suppressants, neuromodulators, prokinetics, and others, but none of these methods are consistently effective. Recent research has found that alterations in gut flora may play an important role in the pathogenesis of FD, especially changes in duodenal microbiome may be caused or contributed to by immune and neuronal dysregulation ( 71 , 75 , 76 ). Restoring microbial homeostasis with probiotics has been shown to be effective in FD ( 77 , 78 ).…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of interstitial cells of Cajal research

Li,

Xiao,

Zhou

et al. 2024

Front. Med.

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ObjectiveThe significance of interstitial cells of Cajal (ICC) in the gastrointestinal tract has garnered increasing attention. In recent years, approximately 80 articles on ICC have been published annually in various journals. However, no bibliometric study has specifically focused on the literature related to ICC. Therefore, we conducted a comprehensive bibliometric analysis of ICC to reveal dynamic scientific developments, assisting researchers in exploring hotspots and emerging trends while gaining a global perspective.MethodsWe conducted a literature search in the Web of Science Core Collection (WoSCC) from January 1, 2013, to December 31, 2023, to identify relevant literature on ICC. We employed bibliometric software, namely VOSviewer and CiteSpace, to analyze various aspects including annual publication output, collaborations, research hotspots, current status, and development trends in this domain.ResultsA total of 891 English papers were published in 359 journals by 928 institutions from 57 countries/regions. According to the keyword analysis of the literature, researchers mainly focused on “c-Kit,” “expression,” “smooth muscle,” and “nitric oxide” related to ICC over the past 11 years. However, with “SIP syncytium,” “ANO1,” “enteric neurons,” “gastrointestinal stromal tumors (GIST),” and “functional dyspepsia (FD),” there has been a growing interest in the relationship between ANO1, SIP syncytium, and ICC, as well as the role of ICC in the treatment of GIST and FD.ConclusionBibliometric analysis has revealed the current status of ICC research. The association between ANO1, SIP syncytium, enteric neurons and ICC, as well as the role of ICC in the treatment of GIST versus FD has become the focus of current research. However, further research and collaboration on a global scale are still needed. Our analysis is particularly valuable to researchers in gastroenterology, oncology, and cell biology, providing insights that can guide future research directions.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of interstitial cells of Cajal research

Li,

Xiao,

Zhou

et al. 2024

Front. Med.

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“…Previous studies have reported the impact of alterations in duodenal microbiota on gastric emptying and mild duodenal inflammation in patients with FD [10,11]. Notably, probiotics have been suggested as a promising therapeutic approach for FD [12,13]. However, the alterations in fecal microbiota among patients with FD and the potential association between microbiota and serum metabolites remain unaddressed.…”

Section: Introductionmentioning

confidence: 99%

Metabolite and Gut Microbiota Profiles in Patients with Functional Dyspepsia: An Integrative Multi-omics Analysis

Wen,

Liang,

et al. 2024

Preprint

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Background: The pathophysiology of functional dyspepsia (FD) remains insufficiently understood, and the pain and economic constraints associated with endoscopic examinations hinder the precise definition and treatment of this disorder. Exploring the potential of multi-omics biomarkers for FD could yield promising targets for effectively diagnosing and treating this condition. Methods: We recruited 54 FD patients and 29 healthy volunteers and characterized their gut microbiota by shotgun metagenomic sequencing and their serum and urine metabolites by liquid chromatography-mass spectrometry (LC-MS). Results: We identified the changes in circulating metabolites associated with FD and linked to the gut microbial alterations. Among the differential circulating metabolites, we particularly highlighted the strong association of L-glutamate deficiency with the severity of FD symptoms and its strong predictive value for FD. Although no significant changes were noted in the gut microbial community structure of the FD samples, this might be attributed to symptom overlap between epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS). However, significant alterations in the abundance of certain species were observed, including a substantial increase in the abundance of Streptococcus in the digestive tract of patients with FD. Finally, a cross-omics correlation network integrating metabolomic data with microbial community abundance was established, uncovering potential host-microbe-metabolite interactions. Conclusions: This work provides the first comprehensive description of the disrupted state of blood and urine metabolite composition and gut microbiota in patients with FD. These findings potentially offer promising targets for the diagnosis and treatment of this condition through a multi-omics approach, with particular emphasis on serum metabolomics.

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