Targeting TFF3 in obstructive airway diseases: a computational approach to novel therapeutics
Alireza Shahriary,
Mohsen Sisakht,
Masoud Arabfard
et al.
Abstract:Background
Airway remodeling, a hallmark of chronic obstructive pulmonary disease (COPD) and Mustard lung disease, is influenced by the Trefoil Factor 3 (TFF3). This study sought to pinpoint a compound with minimal toxicity that can effectively suppress TFF3 expression and activity.
Methods and Results
We employed an integrative approach, combining gene expression analysis, molecular docking, and molecular dynamics simulations, to identify potential TFF3 inhibitors. The biological safety of these compounds w… Show more
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