Targeting T regulatory (Treg) cells in immunotherapy-resistant cancers
Pavlina Spiliopoulou,
Paramjit Kaur,
Tracey Hammett
et al.
Abstract:Primary or secondary (i.e., acquired) resistance is a common occurrence in cancer patients and is often associated with high numbers of T regulatory (Treg) cells (CD4+CD25+FOXP3+). The approval of ipilimumab and the development of similar pharmacological agents targeting cell surface proteins on Treg cells demonstrates that such intervention may overcome resistance in cancer patients. Hence, the clinical development and subsequent approval of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) targeting agents can serve… Show more
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