Targeting Stem Cells in Head and Neck Cancer Using Superparamagnetic Iron Oxide Nanoparticles

Thompson, A.; Thapa, Ranjeeta; Galoforo, Sandra; Hang, XiaoDong; Buelow, Katie L.; Wilson, George

doi:10.1016/j.ijrobp.2017.06.2098

Cited by 5 publications

(3 citation statements)

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“…Many strategies are under investigation in order to improve HNC cancer metastasis treatments and therapies. Nanomaterials, thanks to their suitable properties such as small size, selective ligands functionalization, drug protection and vehiculation, suitable retention in the diseased site and modulated responses according to the applied stimulus (endogenous or exogeneous), are becoming increasingly used both in therapy and diagnostic (theranostic application) [24][25][26]. NMs have the potential to enhance chemotherapy efficiency without increasing toxicity showing many encouraging results demonstrated by preclinical and clinical trials for HNC cancer and metastasis treatments.…”

Section: Discussionmentioning

confidence: 99%

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"Nanomaterials in Head & Neck Cancer Metastasis Treatment: A Mini-Review"

Pisani¹,

Pisani

2021

BJSTR

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Head and Neck cancer (HNC) is a complex and heterogeneous disease associated with high incidence of disseminated metastasis. Traditional oncologic treatment resulted ineffective for a total regression of the disease. Nanomedicine is emerging as innovative and useful therapeutic approach able to overcome limitations of current treatments. A variety of Nanomaterials (NMs) are under investigation in preclinical and clinical trials to validate and guarantee the safety and effective use of NMs against Head and neck metastatic cancer.

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Section: Discussionmentioning

confidence: 99%

“…Hyaluronic Acid (HA) [24] Silver Nanoparticles (AgNPs) - [25] Gold nanoparticles (AuNPs) Enhance X-ray irradiation [26] PEGylated liposome rhenium-188 (188Re) [27] GE11-coniugated liposome Resveratrol (RSV) [28]…”

Section: Nanotechnology-based Therapymentioning

confidence: 99%

"Nanomaterials in Head & Neck Cancer Metastasis Treatment: A Mini-Review"

Pisani¹,

Pisani

2021

BJSTR

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“…The apoptotic rate increased from 1.4% to 27.5% in the CD44 positive cells, indicating the successful targeting of HA-DESPIONs to UT-SCC-14 cells, due to the overexpressed surface receptor CD44. The activation of HA-DESPIONs due to the presence of an AMF generated a significant localized temperature increase that ultimately led to tumor cell death [ 105 ]. Another work that showed advances in fighting and killing CSCs resistant to conventional therapies was that performed by Su et al (2019), in which they also targeted the CD44 population by using MFH.…”

Section: Nanocarriers For Hnc Diagnosis and Treatmentmentioning

confidence: 99%

Insights into Nanomedicine for Head and Neck Cancer Diagnosis and Treatment

2022

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Head and neck cancers rank sixth among the most common cancers today, and the survival rate has remained virtually unchanged over the past 25 years, due to late diagnosis and ineffective treatments. They have two main risk factors, tobacco and alcohol, and human papillomavirus infection is a secondary risk factor. These cancers affect areas of the body that are fundamental for the five senses. Therefore, it is necessary to treat them effectively and non-invasively as early as possible, in order to do not compromise vital functions, which is not always possible with conventional treatments (chemotherapy or radiotherapy). In this sense, nanomedicine plays a key role in the treatment and diagnosis of head and neck cancers. Nanomedicine involves using nanocarriers to deliver drugs to sites of action and reducing the necessary doses and possible side effects. The main purpose of this review is to give an overview of the applications of nanocarrier systems to the diagnosis and treatment of head and neck cancer. Herein, several types of delivery strategies, radiation enhancement, inside-out hyperthermia, and theragnostic approaches are addressed.

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