Targeting <scp>lncRNA</scp>/Wnt axis by flavonoids: A promising therapeutic approach for colorectal cancer

Han, Shuai; Cao, Yunyun; Guo, Tianyi; Lin, Qinlu; Luo, Feijun

doi:10.1002/ptr.7550

Cited by 9 publications

(3 citation statements)

References 188 publications

(169 reference statements)

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“…For example, flavonoids are negatively correlated with the risk of colorectal cancer. These bioactive compounds can target the lncRNA/Wnt pathway to reduce the side effects of anticancer drugs ( 187 ). Simvastatin, a potential therapeutic drug for colorectal cancer immunotherapy, promotes anti-tumor immunity by inhibiting lncRNA SNHG29-mediated YAP activation and inhibiting PD-L1 expression ( 188 ).…”

Section: Summary and Future Prospectsmentioning

confidence: 99%

LncRNAs as potential prognosis/diagnosis markers and factors driving drug resistance of osteosarcoma, a review

Hu,

Han,

Liu

et al. 2024

Front. Endocrinol.

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Osteosarcoma is a common malignancy that often occurs in children, teenagers and young adults. Although the treatment strategy has improved, the results are still poor for most patients with metastatic or recurrent osteosarcomas. Therefore, it is necessary to identify new and effective prognostic biomarkers and therapeutic targets for diseases. Human genomes contain lncRNAs, transcripts with limited or insufficient capacity to encode proteins. They have been implicated in tumorigenesis, particularly regarding the onset, advancement, resistance to treatment, recurrence and remote dissemination of malignancies. Aberrant lncRNA expression in osteosarcomas has been reported by numerous researchers; lncRNAs have the potential to exhibit either oncogenic or tumor-suppressing behaviors and thus, to govern the advancement of this skeletal cancer. They are suspected to influence osteosarcoma cell growth, replication, invasion, migration, remote dissemination and programmed cell death. Additionally, they have been recognized as clinical markers, and may participate in the development of multidrug resistance. Therefore, the study of lncRNAs in the growth, metastasis, treatment and prognosis of osteosarcoma is very important for the active prevention and treatment of osteosarcoma. Consequently, this work reviews the functions of lncRNAs.

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Section: Summary and Future Prospectsmentioning

confidence: 99%

LncRNAs as potential prognosis/diagnosis markers and factors driving drug resistance of osteosarcoma, a review

Hu,

Han,

Liu

et al. 2024

Front. Endocrinol.

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“…We have also noted that few previous reviews have focused on using plant extracts and fractions rich in phenols and pure phenolic compounds [25,26]. Some have examined flavonoids and their effects on CRC [27][28][29][30][31][32][33][34][35][36], yet no such reviews consider other classes of phenolic compounds and their effects on CRC. In contrast, numerous reviews were dedicated to discussing the deadly disease of CRC, but did not examine natural products for its treatment.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Phytochemicals for Prevention and Treatment of Colorectal Cancer: A Critical Evaluation of In Vivo Studies

Paul

Manna

et al. 2023

Cancers

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Colorectal cancer (CRC) is the third most diagnosed and second leading cause of cancer-related death worldwide. Limitations with existing treatment regimens have demanded the search for better treatment options. Different phytochemicals with promising anti-CRC activities have been reported, with the molecular mechanism of actions still emerging. This review aims to summarize recent progress on the study of natural phenolic compounds in ameliorating CRC using in vivo models. This review followed the guidelines of the Preferred Reporting Items for Systematic Reporting and Meta-Analysis. Information on the relevant topic was gathered by searching the PubMed, Scopus, ScienceDirect, and Web of Science databases using keywords, such as “colorectal cancer” AND “phenolic compounds”, “colorectal cancer” AND “polyphenol”, “colorectal cancer” AND “phenolic acids”, “colorectal cancer” AND “flavonoids”, “colorectal cancer” AND “stilbene”, and “colorectal cancer” AND “lignan” from the reputed peer-reviewed journals published over the last 20 years. Publications that incorporated in vivo experimental designs and produced statistically significant results were considered for this review. Many of these polyphenols demonstrate anti-CRC activities by inhibiting key cellular factors. This inhibition has been demonstrated by antiapoptotic effects, antiproliferative effects, or by upregulating factors responsible for cell cycle arrest or cell death in various in vivo CRC models. Numerous studies from independent laboratories have highlighted different plant phenolic compounds for their anti-CRC activities. While promising anti-CRC activity in many of these agents has created interest in this area, in-depth mechanistic and well-designed clinical studies are needed to support the therapeutic use of these compounds for the prevention and treatment of CRC.

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“…Furthermore, lncRNAs are dysregulated in several malignancies, and they are regarded as important prognostic and diagnostic biomarkers because of their distinct expression patterns and high tissue-and cell-specificity (7). In addition, recent research has demonstrated that lncRNAs may be involved in migration, metastasis, chemoresistance, epithelial-to-mesenchymal transition (EMT), and proliferation of CRC (8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

lncRNA VLDLR-AS1 Gene Expression in Colorectal Cancer in Patients from East Azerbaijan Province, Iran

Moqadami,

Ahmadi,

Khalaj-Kondori

2023

Jentashapir J Cell Mol Biol

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Background: Colorectal cancer (CRC) is the third most common cancer that frequently spreads to other parts of the body, with a low chance of recovery and a high mortality rate. Long non-coding RNAs are considered significant prognostic and diagnostic indicators because they are dysregulated in various cancers and have distinctive expression patterns and high tissue- and cell-specificity. VLDLR-AS1 lncRNA deregulation has been associated with several malignancies. Objectives: This study aimed to evaluate the expression levels of VLDLR-AS1 in CRC. It was the first time this assessment was conducted. Methods: We studied 188 samples, including 94 tumor samples and 94 paired adjacent non-tumor tissues. Total RNA was extracted, and its quantity and purity were assessed. TaKaRa PrimeScript 1st Strand cDNA Synthesis Kit (Kusatsu, Japan) was used for the reaction. The StepOnePlus Real-Time PCR System (Applied Biosystems) was set up to assess the relative expression of VLDLR-AS1. Results: According to the qRT-PCR data, the VLDLR-AS1 expression levels in CRC tissues were significantly lower than in tumor margins (P < 0.0001). In addition, receiver operating characteristic curve analysis demonstrated that VLDLR-AS1 expression can discriminate between tumor and non-tumor samples with the sensitivity and specificity of 72.34% and 51.06%, respectively (P = 0.03, AUC = 0.6274). However, no significant association was found between the expression levels of VLDLR-AS1 and clinicopathological features in CRC patients. Conclusions: The results of this study indicated that VLDLR-AS1 lncRNA is significantly downregulated in the tumor tissues of CRC patients compared to healthy tumor margin tissues. This evidence shows the potential of this gene as a promising biomarker for the early detection of CRC development.

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Targeting lncRNA/Wnt axis by flavonoids: A promising therapeutic approach for colorectal cancer

Cited by 9 publications

References 188 publications

LncRNAs as potential prognosis/diagnosis markers and factors driving drug resistance of osteosarcoma, a review

LncRNAs as potential prognosis/diagnosis markers and factors driving drug resistance of osteosarcoma, a review

Phenolic Phytochemicals for Prevention and Treatment of Colorectal Cancer: A Critical Evaluation of In Vivo Studies

lncRNA VLDLR-AS1 Gene Expression in Colorectal Cancer in Patients from East Azerbaijan Province, Iran

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