Targeting Redox Regulation as a Therapeutic Opportunity against Acute Leukemia: Pro-Oxidant Strategy or Antioxidant Approach?

Allegra, Alessandro; Tonacci, Alessandro; Giordano, Laura; Musolino, Caterina; Gangemi, Sebastiano

doi:10.3390/antiox11091696

Cited by 7 publications

(8 citation statements)

References 150 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ROS are regarded as double-edged swords and are the main contributors to oxidative stress. Low levels of ROS function as vital second messengers, but at high concentrations, they are cytotoxic agents in both cancer cells and healthy cells [ 31 ]. Elevated ROS reduces the differentiation and self-renewal capacity of hematopoietic stem cells (HSCs), resulting in rapid bone marrow failure for which there is no successful treatment [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

The ferroptosis landscape in acute myeloid leukemia

Ma,

Ye,

Huang

et al. 2023

Aging

View full text Add to dashboard Cite

Ferroptosis induction through the suppression of glutathione peroxidase 4 (GPX4) and apoptosis-inducing factor mitochondria-associated 2 (AIFM2) has proven to be an effective approach in eliminating chemotherapy-resistant cells of various types. However, a comprehensive understanding of the roles of GPX4 and AIFM2 in acute myeloid leukemia (AML) has not yet been achieved. Using cBioPortal, DepMap, GEPIA, Metascape, and ONCOMINE, we compared the transcriptional expression, survival data, gene mutation, methylation, and network analyses of GPX4- and AIFM2-associated signaling pathways in AML. The results revealed that high expression levels of GPX4 and AIFM2 are associated with an adverse prognosis for AML patients. Overexpression of AIFM2 correlated with elevated mutation frequencies in NPM1 and DNMT3A. GPX4 upregulation modulated the following pathways: GO:0045333, cellular respiration; R-HSA-5389840, mitochondrial translation elongation; GO:0009060, aerobic respiration; R-HSA-9609507, protein localization; and R-HSA-8953854, metabolism of RNA. On the other hand, the overexpression of AIFM2 influenced the following processes: GO:0048704, embryonic skeletal system morphogenesis; GO:0021546, rhombomere development; GO:0009954, proximal/distal pattern formation; and GO:0048732, gland development. This study identifies the high expression of GPX4 and AIFM2 as novel biomarkers predicting a poor prognosis for AML patients. Furthermore, ferroptosis induction may improve the stratified treatment of AML.

show abstract

Section: Discussionmentioning

confidence: 99%

The ferroptosis landscape in acute myeloid leukemia

Ma,

Ye,

Huang

et al. 2023

Aging

View full text Add to dashboard Cite

show abstract

“…On the contrary, increased ROS concentration also can be an efficient system to destroy leukemia cells ( Allegra et al, 2022 ). Therefore, further clinical big data research is needed on the need for antioxidant adjuvant therapy ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

The progress in the relationship between trace elements and acute lymphoblastic leukemia

Wang

Huang²,

Lang³

et al. 2023

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Trace elements are very important substances with low content in the human body. If the content of some trace elements changes, they are also related to diseases. Acute lymphoblastic leukemia (ALL) is a malignant blood tumor, and its relationship with trace elements has also been a concern by scholars. Not only have the trace element levels in ALL patients changed, but the efficacy of different treatment methods has also been linked to the corresponding trace element changes. The characteristics of ALL may be related to the dysregulation of differentiation and proliferation of lymphoid precursor cells. Cell proliferation and differentiation are often affected by changes in DNA levels. However, trace elements are involved in DNA damage and repair mechanisms. In recent years, as an increasing number of studies believe that ALL is related to the abnormal metabolism of trace elements in the body, this paper intends to discuss the research progress on the relationship between trace elements and ALL to provide more information on trace elements for the diagnosis, treatment, and prevention of ALL.

show abstract

“…The term oxidative stress identifies an alteration of the balance between the levels of reactive oxygen species (ROS) and the activity of cellular antioxidant mechanisms in favor of the former, which can lead to potential damage [ 28 , 29 , 30 ]. ROS perform a dual role, because, at physiological concentrations, they carry out very important functions at cellular and systemic levels.…”

Section: Introductionmentioning

confidence: 99%

“…They are involved in cellular responses against pathogens and participate in ordinary cellular signaling pathways [ 31 ], while excess ROS can lead to genomic and mitochondrial DNA damage, which in turn leads to molecular mutations and altered signaling pathways [ 1 ]. The genesis of ROS can be exogenous or endogenous; mitochondria, peroxisomes, and activated inflammatory cells, such as macrophages, neutrophils, and eosinophils, represent the main endogenous sources [ 30 , 32 , 33 ]. Regarding the production of exogenous ROS, these can be generated by ionizing radiation [ 34 ] or by xenobiotics (pharmaceutical or environmental chemicals) [ 1 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

“…The genesis of ROS can be exogenous or endogenous; mitochondria, peroxisomes, and activated inflammatory cells, such as macrophages, neutrophils, and eosinophils, represent the main endogenous sources [ 30 , 32 , 33 ]. Regarding the production of exogenous ROS, these can be generated by ionizing radiation [ 34 ] or by xenobiotics (pharmaceutical or environmental chemicals) [ 1 , 30 ]. The main source of intracellular ROS is represented by mitochondria, which generate superoxide radicals during oxidative phosphorylation [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders

Cancemi,

Cicero,

Allegra

et al. 2023

Antioxidants

Self Cite

View full text Add to dashboard Cite

Lymphomas are a heterogeneous group of pathologies that result from clonal proliferation of lymphocytes. They are classified into Hodgkin lymphoma and non-Hodgkin lymphoma; the latter develops as a result of B, T, or NK cells undergoing malignant transformation. It is believed that diet can modulate cellular redox state and that oxidative stress is implicated in lymphomagenesis by acting on several biological mechanisms; in fact, oxidative stress can generate a state of chronic inflammation through the activation of various transcription factors, thereby increasing the production of proinflammatory cytokines and causing overstimulation of B lymphocytes in the production of antibodies and possible alterations in cellular DNA. The purpose of our work is to investigate the results of in vitro and in vivo studies on the possible interaction between lymphomas, oxidative stress, and diet. A variety of dietary regimens and substances introduced with the diet that may have antioxidant and antiproliferative effects were assessed. The possibility of using nutraceuticals as novel anticancer agents is discussed; although the use of natural substances in lymphoma therapy is an interesting field of study, further studies are needed to define the efficacy of different nutraceuticals before introducing them into clinical practice.

show abstract

Targeting Redox Regulation as a Therapeutic Opportunity against Acute Leukemia: Pro-Oxidant Strategy or Antioxidant Approach?

Cited by 7 publications

References 150 publications

The ferroptosis landscape in acute myeloid leukemia

The ferroptosis landscape in acute myeloid leukemia

The progress in the relationship between trace elements and acute lymphoblastic leukemia

Effect of Diet and Oxidative Stress in the Pathogenesis of Lymphoproliferative Disorders

Contact Info

Product

Resources

About