2008
DOI: 10.1007/s10072-008-0986-2
|View full text |Cite
|
Sign up to set email alerts
|

Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson’s disease

Abstract: Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer's disease. The main clinical features of PD include tremor, bradykinesia, rigidity and postural instability. The primary pathology of PD is degeneration of dopaminergic neurons in the substantia nigra pars compacta, resulting in loss of the nigrostriatal pathway and a reduction of dopamine contents in the striatum. The biochemical and cellular changes that occur following the administration of 1-methyl-4-phenyl-1,2,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
41
0

Year Published

2009
2009
2021
2021

Publication Types

Select...
6
3
1

Relationship

0
10

Authors

Journals

citations
Cited by 77 publications
(42 citation statements)
references
References 80 publications
1
41
0
Order By: Relevance
“…Thus, DMF treatment, in particular mostly at the dose of 30 mg/kg, inhibiting the nuclear translocation of NF-jB and promoting the transcription of IjB-a, points toward representing a functional system for regulation of neuroinflammation in response to oxidative stress in the brain. However, oxidative stress is intimately linked as well not only to inflammation but also to other components of the neurodegenerative process, such as nitrosative stress (68). Various isoforms of the nitric oxide (NO) producing enzyme nitric oxide synthase (NOS) are elevated in PD, indicating an important critical role for NO in disease of the pathophysiology mechanisms, considering that increased expression of glial and neuronal NOS isoforms in astrocytes and neurons contributes to the synthesis of peroxynitrite synthesis, which leads to the generation of NT (nitrotyrosine) (27).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, DMF treatment, in particular mostly at the dose of 30 mg/kg, inhibiting the nuclear translocation of NF-jB and promoting the transcription of IjB-a, points toward representing a functional system for regulation of neuroinflammation in response to oxidative stress in the brain. However, oxidative stress is intimately linked as well not only to inflammation but also to other components of the neurodegenerative process, such as nitrosative stress (68). Various isoforms of the nitric oxide (NO) producing enzyme nitric oxide synthase (NOS) are elevated in PD, indicating an important critical role for NO in disease of the pathophysiology mechanisms, considering that increased expression of glial and neuronal NOS isoforms in astrocytes and neurons contributes to the synthesis of peroxynitrite synthesis, which leads to the generation of NT (nitrotyrosine) (27).…”
Section: Discussionmentioning
confidence: 99%
“…lular and extracelluar damage to local neurons (55). The SN also has a very high iron content (48), which may further exacerbate oxidative damage by reacting with byproducts of DA metabolism to generate highly reactive radicals (16).…”
Section: Discussionmentioning
confidence: 99%
“…MPP ϩ interferes with the mitochondrial complex-1, generates reactive oxygen species (ROS) and selectively damages dopaminergic neurons (15). Dopamine itself is also a highly-reactive molecule and naturally metabolized to produce ROS including hydrogen peroxide (H 2 O 2 ) via the monoamine oxidase pathway (16).…”
Section: Parkinson Disease (Pd)mentioning
confidence: 99%