Targeting Rab-RILPL Interactions as a Strategy to Downregulate Pathogenic LRRK2 in Parkinson’s Disease
Krista K. Alexander,
Yahaira Naaldijk,
Rachel Fasiczka
et al.
Abstract:Familial Parkinson’s disease (PD) is frequently linked to multiple disease-causing mutations within Leucine-Rich Repeat Protein Kinase 2 (LRRK2), leading to aberrant kinase activity. Multiple pathogenic effects of enhanced LRRK2 activity have been identified including loss of cilia and centrosomal cohesion defects. When phosphorylated by LRRK2, Rab8a and Rab10 bind to phospho-specific RILPL effector proteins. RILPL-mediated accumulation of pRabs proximal to the mother centriole is critical for initiating defic… Show more
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