Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy

He, Xin; Liu, Jie; Xiao, Xiaojun; Zhang, Shuang; Wang, Xinxin; Liu, Jiangqi; Liu, Zhiqiang; Wang, Junyi; Liu, Xiaoyu; Li, Guoping; Yang, Ping‐Chang

doi:10.7150/thno.78851

Cited by 2 publications

(1 citation statement)

References 29 publications

(43 reference statements)

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“…Given the patterns of sensitization and exposure to major indoor allergens in the study population, it is not possible to examine mediation effects by specific allergens. It is also possible that reductions in stress may have attenuated the effects of allergen exposure, given literature that shows that psychological stress can enhance the influence of allergens on allergy and asthma correlates …”

Section: Discussionmentioning

confidence: 99%

Association of a Housing Mobility Program With Childhood Asthma Symptoms and Exacerbations

Pollack,

Roberts,

Peng

et al. 2023

JAMA

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ImportanceStructural racism has been implicated in the disproportionally high asthma morbidity experienced by children living in disadvantaged, urban neighborhoods. Current approaches designed to reduce asthma triggers have modest impact.ObjectiveTo examine whether participation in a housing mobility program that provided housing vouchers and assistance moving to low-poverty neighborhoods was associated with reduced asthma morbidity among children and to explore potential mediating factors.Design, Setting, and ParticipantsCohort study of 123 children aged 5 to 17 years with persistent asthma whose families participated in the Baltimore Regional Housing Partnership housing mobility program from 2016 to 2020. Children were matched to 115 children enrolled in the Urban Environment and Childhood Asthma (URECA) birth cohort using propensity scores.ExposureMoving to a low-poverty neighborhood.Main OutcomesCaregiver-reported asthma exacerbations and symptoms.ResultsAmong 123 children enrolled in the program, median age was 8.4 years, 58 (47.2%) were female, and 120 (97.6%) were Black. Prior to moving, 89 of 110 children (81%) lived in a high-poverty census tract (&gt;20% of families below the poverty line); after moving, only 1 of 106 children with after-move data (0.9%) lived in a high-poverty tract. Among this cohort, 15.1% (SD, 35.8) had at least 1 exacerbation per 3-month period prior to moving vs 8.5% (SD, 28.0) after moving, an adjusted difference of −6.8 percentage points (95% CI, −11.9% to −1.7%; P = .009). Maximum symptom days in the past 2 weeks were 5.1 (SD, 5.0) before moving and 2.7 (SD, 3.8) after moving, an adjusted difference of −2.37 days (95% CI, −3.14 to −1.59; P &lt; .001). Results remained significant in propensity score–matched analyses with URECA data. Measures of stress, including social cohesion, neighborhood safety, and urban stress, all improved with moving and were estimated to mediate between 29% and 35% of the association between moving and asthma exacerbations.Conclusions and RelevanceChildren with asthma whose families participated in a program that helped them move into low-poverty neighborhoods experienced significant improvements in asthma symptom days and exacerbations. This study adds to the limited evidence suggesting that programs to counter housing discrimination can reduce childhood asthma morbidity.

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Section: Discussionmentioning

confidence: 99%

Association of a Housing Mobility Program With Childhood Asthma Symptoms and Exacerbations

Pollack,

Roberts,

Peng

et al. 2023

JAMA

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Regulation of SETD2 maintains immune regulatory function in macrophages to suppress airway allergy

Zhang,

Wang,

Liu

et al. 2024

Immunology

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SET domain‐containing 2 (SETD2) is a histone methyltransferase. It regulates the activity of H3K36me3 to enhance gene transcription. Macrophages (Mϕs) are one of the cell types involved in immune response. The purpose of this study is to clarify the role of SETD2 in regulating the immune property of Mϕ. The Mφs were isolated from the bronchoalveolar lavage fluid (BALF) and analysed through flow cytometry and RNA sequencing. A mouse strain carrying Mφs deficient in SETD2 was used. A mouse model of airway allergy was established with the ovalbumin/alum protocol. Less expression of SETD2 was observed in airway Mϕs in patients with allergic asthma. SETD2 of M2 cells was associated with the asthmatic clinical response. Sensitization reduced the expression of SETD2 in mouse respiratory tract M2 cells, which is associated with the allergic reaction. Depletion of SETD2 in Mφs resulted in Th2 pattern inflammation in the lungs. SETD2 maintained the immune regulatory ability in airway M2 cells. SETD2 plays an important role in the maintenance of immune regulatory property of airway Mφs.

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Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy

Cited by 2 publications

References 29 publications

Association of a Housing Mobility Program With Childhood Asthma Symptoms and Exacerbations

Association of a Housing Mobility Program With Childhood Asthma Symptoms and Exacerbations

Regulation of SETD2 maintains immune regulatory function in macrophages to suppress airway allergy

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