Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy

Jia, Xiangqian; Han, Qiuju; Wang, Zihua; Qian, Yixia; Jia, Yunhong; Wang, Weizhi; Hu, Zhiyuan

doi:10.1039/c6bm00898d

Cited by 13 publications

(6 citation statements)

References 17 publications

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“…As a result, Slp-coated liposomes have received increasing attention in the past decade. Liposomes are nanovesicles composed of phospholipid bilayers that have various beneficial characteristics, such as good cell affinity, 7,8 targeting properties, [9][10][11] and sustained drug-release behavior. 12 Due to their favorable ability to encapsulate both hydrophobic and hydrophilic drugs, liposomes are widely used as carriers for bioactive drugs, including antineoplastic drugs, 13,14 antimicrobial drugs, 15 antiparasitic drugs, 16 hormonal drugs, 17 proteins, 18,19 and nucleic acid drugs 20,21 such as DNA [22][23][24] and siRNA.…”

Section: Introductionmentioning

confidence: 99%

<p>Slp-coated liposomes for drug delivery and biomedical applications: potential and challenges</p>

Luo¹,

Yang²,

Yao³

et al. 2019

IJN

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Slp forms a crystalline array of proteins on the outermost envelope of bacteria and archaea with a molecular weight of 40-200 kDa. Slp can self-assemble on the surface of liposomes in a proper environment via electrostatic interactions, which could be employed to functionalize liposomes by forming Slp-coated liposomes for various applications. Among the molecular characteristics, the stability, adhesion, and immobilization of biomacromolecules are regarded as the most meaningful. Compared to plain liposomes, Slp-coated liposomes show excellent physicochemical and biological stabilities. Recently, Slp-coated liposomes were shown to specifically adhere to the gastrointestinal tract, which was attributed to the "ligand-receptor interaction" effect. Furthermore, Slp as a "bridge" can immobilize functional biomacromolecules on the surface of liposomes via protein fusion technology or intermolecular forces, endowing liposomes with beneficial functions. In view of these favorable features, Slp-coated liposomes are highly likely to be an ideal platform for drug delivery and biomedical uses. This review aims to provide a general framework for the structure and characteristics of Slp and the interactions between Slp and liposomes, to highlight the unique properties and drug delivery as well as the biomedical applications of the Slp-coated liposomes, and to discuss the ongoing challenges and perspectives.

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Section: Introductionmentioning

confidence: 99%

<p>Slp-coated liposomes for drug delivery and biomedical applications: potential and challenges</p>

Luo¹,

Yang²,

Yao³

et al. 2019

IJN

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“…This adds to the retention of natural homeostasis in a biological environment and reduction in the entry of water into the LNPs to avoid premature degradation [ 84 ]. This was validated in a study where LNPs were shown to specifically target tumor sites, including the glioblastoma regions [ 86 , 87 ]. A comparable xenobiotic metabolism was noted in LNPs and food-based lipids that were internally degraded into nontoxic residues.…”

Section: Lnps and The Blood–brain Barriermentioning

confidence: 94%

Lipid Nanoparticles: Promising Treatment Approach for Parkinson’s Disease

Jagaran

Singh

2022

IJMS

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Parkinson’s disease (PD), a neurodegenerative disorder, is a life-altering, debilitating disease exhibiting a severe physical, psychological, and financial burden on patients. Globally, approximately 7–10 million people are afflicted with this disease, with the number of cases estimated to increase to 12.9 million by 2040. PD is a progressive movement disorder with nonmotor symptoms, including insomnia, depression, anxiety, and anosmia. While current therapeutics are available to PD patients, this treatment remains palliative, necessitating alternative treatment approaches. A major hurdle in treating PD is the protective nature of the blood–brain barrier (BBB) and its ability to limit access to foreign molecules, including therapeutics. Drugs utilized presently are nonspecific and administered at dosages that result in numerous adverse side effects. Nanomedicine has emerged as a potential strategy for treating many diseases. From the array of nanomaterials available, lipid nanoparticles (LNPs) possess various advantages, including enhanced permeability to the brain via passive diffusion and specific and nonspecific transporters. Their bioavailability, nontoxic nature, ability to be conjugated to drugs, and targeting moieties catapult LNPs as a promising therapeutic nanocarriers for PD. While PD-related studies are limited, their potential as therapeutics is evident in their formulations as vaccines. This review is aimed at examining the roles and properties of LNPs that make them efficient therapeutic nanodelivery vehicles for the treatment of PD, including therapeutic advances made to date.

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“…Structural modifications or the addition of targeting sequences to the molecule may improve its imaging properties. Conversely, Jia et al strengthened the APN/CD13 tumour-homing ability of YEVGHRC peptide-functionalised liposomes [ 75 ]. They reported that such liposomes could serve as useful tools to carry nano-encapsulated drugs to APN/CD13 expressing tumours under in vitro and in vivo conditions.…”

Section: Overview Of Preclinical Studies With Radiolabelled Ngr-based...mentioning

confidence: 99%

“…Taking into account that the NGR sequence is prone to the deamidation of the Asn side chain, the establishment of less vulnerable APN/CD13 specific peptides is of pivotal importance in angiogenesis imaging [74]. Initial research findings are already available on the diagnostic performance of novel linear sequences directed towards angiogenesis associated biomarkers [40,75]. In a former proof-of-concept study by Dénes et al, the in vivo behaviour of [ 68 Ga]Ga-labelled c(NGR) peptide and linear LN peptide YEVGHRC (tyrosyl-glutamyl-valyl-glycyl-histidyl-arginyl-cysteine)-based radiotracers was studied at the preclinical level (seen in Figure 2) [40].…”

Section: Cendr Sequence-containing Ngr-based Probementioning

confidence: 99%

NGR-Based Radiopharmaceuticals for Angiogenesis Imaging: A Preclinical Review

Trencsényi

Enyedi

Mező

et al. 2023

IJMS

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Angiogenesis plays a crucial role in tumour progression and metastatic spread; therefore, the development of specific vectors targeting angiogenesis has attracted the attention of several researchers. Since angiogenesis-associated aminopeptidase N (APN/CD13) is highly expressed on the surface of activated endothelial cells of new blood vessels and a wide range of tumour cells, it holds great promise for imaging and therapy in the field of cancer medicine. The selective binding capability of asparagine-glycine-arginine (NGR) motif containing molecules to APN/CD13 makes radiolabelled NGR peptides promising radiopharmaceuticals for the non-invasive, real-time imaging of APN/CD13 overexpressing malignancies at the molecular level. Preclinical small animal model systems are major keystones for the evaluation of the in vivo imaging behaviour of radiolabelled NGR derivatives. Based on existing literature data, several positron emission tomography (PET) and single-photon emission computed tomography (SPECT) radioisotopes have been applied so far for the labelling of tumour vasculature homing NGR sequences such as Gallium-68 (68Ga), Copper-64 (64Cu), Technetium-99m (99mTc), Lutetium-177 (177Lu), Rhenium-188 (188Re), or Bismuth-213 (213Bi). Herein, a comprehensive overview is provided of the recent preclinical experiences with radiolabelled imaging probes targeting angiogenesis.

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Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy

Cited by 13 publications

References 17 publications

<p>Slp-coated liposomes for drug delivery and biomedical applications: potential and challenges</p>

<p>Slp-coated liposomes for drug delivery and biomedical applications: potential and challenges</p>

Lipid Nanoparticles: Promising Treatment Approach for Parkinson’s Disease

NGR-Based Radiopharmaceuticals for Angiogenesis Imaging: A Preclinical Review

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