volume 24, issue s2, P223-232 2011
DOI: 10.3233/jad-2011-110182
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Bharathi Shrikanth Gadad, Gabrielle B. Britton, K.S. Rao

Abstract: Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Prion disease, Huntington's disease, and amyotrophic lateral sclerosis are increasingly being realized to have common cellular and molecular mechanisms including protein aggregation and inclusion body formation in selected brain regions. The aggregates usually consist of insoluble fibrillar aggregates containing misfolded protein with β-sheet conformation. The most probable explanation is that inclusions and the aggregates symbolize …

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