Targeting of the respiratory chain by toxicants: beyond the toxicities to mitochondrial morphology

Zhou, Ping‐Kun; Huang, Ruixue

doi:10.1039/c8tx00207j

Cited by 29 publications

(18 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, low levels of PM 2.5 exposure may stimulate the immune system, while high levels may compromise immune function, as environmental genotoxicants have been shown to exert different effects (i.e. harmful or beneficial) depending on molecular and ecological factors [45][46][47]. This study shows that the impacts of these air pollutants on HFMD are complex and require further exploration, particularly of the underlying mechanisms.…”

Section: Discussionmentioning

confidence: 89%

Associations between ambient air pollution and daily incidence of pediatric hand, foot and mouth disease in Ningbo, 2014–2016: a distributed lag nonlinear model

Lü

et al. 2020

Epidemiol. Infect.

View full text Add to dashboard Cite

Hand, foot and mouth disease (HFMD) has high prevalence around the world, with serious consequences for children. Due to the long survival period of HFMD virus in ambient air, air pollutants may play a critical role in HFMD epidemics. We collected data on daily cases of HFMD among children aged 0–14 years in Ningbo City between 2014 and 2016. Distributed lag nonlinear models were used to assess the effects of particulate matter (PM2.5), sulphur dioxide (SO2), nitrogen dioxide (NO2) and ozone (O3) on the daily incidence of HFMD among children, with analyses stratified by gender and age. Compared with moderate levels of air pollution, high SO2 levels had a relative risk (RR) of 2.32 (95% CI 1.42–3.79) and high NO2 levels had a RR of 2.01 (95% CI 1.22–3.31). The RR of O3 was 2.12 (95% CI 1.47–3.05) and that of PM2.5 was 0.77 (95% CI 0.64–0.92) at moderate levels of air pollution. Specifically, high levels of SO2 and NO2 had RRs of 2.39 (95% CI 1.44–3.96) and 2.02 (95% CI 1.21–3.39), respectively, among 0–4-year-old children, while high O3 had an RR of 2.31 (95% CI 1.09–4.89) among 5–14-year-old children. Our findings suggest significant associations of high SO2 and NO2 levels and moderate O3 levels in HFMD epidemics, and also indicate that air pollution causes lagged effects on HFMD epidemics. Our study provides practical and useful data for targeted prevention and control of HMFD based on environmental evidence.

show abstract

Section: Discussionmentioning

confidence: 89%

Associations between ambient air pollution and daily incidence of pediatric hand, foot and mouth disease in Ningbo, 2014–2016: a distributed lag nonlinear model

Lü

et al. 2020

Epidemiol. Infect.

View full text Add to dashboard Cite

show abstract

“…For the first time, we herein identified mRNAs and lncRNAs that were abnormally expressed in human lung fibrosis induced by silica exposure, which exhibits complex pathological changes; no effective therapy is available. Biomarkers discovered via mRNAs and lncRNAs analysis might facilitate diagnosis and therapy [35, 36].…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of lncRNA and mRNA Transcriptomes Reveals New Regulators of Ubiquitination and the Immune Response in Silica-Induced Pulmonary Fibrosis

Zhou

Liu

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Objectives As an epigenetic player, long noncoding RNAs (LncRNAs) have been reported to participate in multiple biological processes; however, their biological functions in silica-induced pulmonary fibrosis (SIPF) occurrence and development remain incompletely understood. Methods Five case/control pairs were used to perform integrated transcriptomes analysis of lncRNA and mRNA. Prediction of lncRNA and mRNA functions was aided by the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Additionally, we constructed a coexpression network of lncRNAs and mRNAs to identify targets of regulation. Results In total, 1069 differentially expressed mRNAs and 366 lncRNAs were identified with the changes more than 2 times (p<0.05), of which 351 downregulated mRNA and 31 downregulated lncRNA were <0.5 (p<0.05) and those of 718 upregulated mRNAs and 335 upregulated lncRNA were >2 (p<0.05). The levels of 10 lncRNAs were measured via qRT-PCR; the results were consistent with the microarray data. Four genes named of FEM1B, TRIM39, TRIM32, and KLHL15 were enriched significantly with ubiquitination and immune response. Cytokine-cytokine receptor interaction was the most significantly enriched KEGG pathway in both mRNAs and lncRNAs. The coexpression network revealed that a single lncRNA can interact with multiple mRNAs, and vice versa. Conclusions lncRNA and mRNA expression were aberrant in patients with SIPF compared to controls, indicating that differentially expressed lncRNAs and mRNAs may play critical roles in SIPF development. Our study affords new insights into the molecular mechanisms of SIPF and identifies potential biomarkers and targets for SIPF diagnosis and treatment.

show abstract

“…Bacteria16S:Silva (release 128, http://www.arb-silva.de) was used for species identification and analysis. Phylogenetic tree analysis was conducted using the neighbor-joining method, and multiple comparisons were performed using PyNAST (version 1.2.2, http://biocore.github.io/pynast/) and ClustalW2 [10] (http://www.ebi.ac.uk/Tools/msa/clustalw2/).…”

Section: Methodsmentioning

confidence: 99%

“…Numerous studies have identified that inhalation of free silicon dioxide or silica is the cause of silicosis, and that the main clinical pathological feature is progressive pulmonary fibrosis [7]. The underlying mechanisms may involve silica-induced cytotoxicity of macrophages, activation of leukocytes to produce reactive oxygen free radicals, and damage to alveolar epithelial cells to induce fibroblast proliferation [8–10]. However, the exact mechanism of progressive pulmonary fibrosis in silicosis remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis

Zhou¹,

Lv²,

Sun

et al. 2019

J Occup Med Toxicol

View full text Add to dashboard Cite

Silicosis resulting from silica exposure is a global occupational disease characterized by severe pathological changes in progressive pulmonary fibrosis. Previous evidence has indicated that dysbiosis of the gut microbiota occurs after environmental dust exposure and is associated with certain diseases. The aims of this study are to elucidate the compositional and functional characteristics of the gut microbiota in early-stage silicosis and to understand their influence on pulmonary fibrosis. We investigated the gut microbial composition of fecal samples from 18 patients and 21 healthy subjects using 16S rRNA gene sequencing technology. Compared with the healthy subjects, reductions in the levels of Firmicutes and Actinobacteria were noted in patients with silicosis and progressive pulmonary fibrosis, as well as lower levels of Devosia, Clostridiales, AlloprevotellaandRikenellaceae_RC9. Lachnospiraceae and Lachnoclostridium levels were increased in patients with silicosis. GOC and KEGG analyses were used to predict that certain bacteria taxa play critical roles in the development of pulmonary fibrosis, including posttranslational modification, amino acid transport and metabolism, nucleotide transport and metabolism, and ribosomal structure and biogenesis. KEGG analysis showed that certain taxa participate in various roles including cancer, endocrine metabolism, immune system, signaling molecules and interaction, and transcription. Collectively, in this pilot study, microbiota changes have been represented in the gut of patients with silicosis. Although this change in gut microbiota have been represented, caution is needed when interpreting the findings since this is observational finding, not necessarily causative. More studies should be performed in the expanding population to be verified and more studies underlying biological mechanisms for better understanding the relationship between gut microbiota and development of pulmonary fibrosis in patients with silicosis.

show abstract

Targeting of the respiratory chain by toxicants: beyond the toxicities to mitochondrial morphology

Abstract: The mitochondrion is an important subcellular target of environmental toxicants.

Cited by 29 publications

References 34 publications

Associations between ambient air pollution and daily incidence of pediatric hand, foot and mouth disease in Ningbo, 2014–2016: a distributed lag nonlinear model

Associations between ambient air pollution and daily incidence of pediatric hand, foot and mouth disease in Ningbo, 2014–2016: a distributed lag nonlinear model

Integrated Analysis of lncRNA and mRNA Transcriptomes Reveals New Regulators of Ubiquitination and the Immune Response in Silica-Induced Pulmonary Fibrosis

Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis

Contact Info

Product

Resources

About