Targeting of gallbladder megalin receptors with DHA-conjugated limonene albumin nanoparticles

Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for a significant proportion of cancer-related deaths worldwide. Although conventional cancer therapies, such as surgical excision, chemotherapy, and radiation, have been used to treat malignant melanoma, their efficacy is often limited due to the development of resistance and adverse side effects. Therefore, there is a growing interest in developing alternative treatment options for melanoma that are more effective and less toxic. Terpenes, a diverse group of naturally occurring compounds of plant origin, have emerged as potential anticancer agents due to their ability to inhibit tumor growth and induce apoptosis in cancer cells. In this review, the current understanding of the anticancer effects of terpenes (including, thymoquinone, β-elemene, carvacrol, limonene, α-pinene, β-caryophyllene, perillyl alcohol, taxol, betulinic acid, α-bisabolol, ursolic acid, linalool, lupeol, and artesunate) was summarized, with a special focus on their potential as therapeutic agents for malignant melanoma.

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Anticancer effect of terpenes: focus on malignant melanoma

Wróblewska-Łuczka

Cabaj

Bargieł

et al. 2023

Pharmacol. Rep

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Causal association of polyunsaturated fatty acids with biliary tract diseases: A Mendelian randomization study

Chen,

Shi,

Zhang

et al. 2024

Clinical Nutrition ESPEN

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Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example

Liu

et al. 2023

Journal of Ethnopharmacology

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Targeting of gallbladder megalin receptors with DHA-conjugated limonene albumin nanoparticles

Abstract: Gallbladder stones is a major pathogenic factor leading to cholecystitis, it is increasingly important to explore innovative drug delivery methods for gallstones. In the present study, docosahexaenoic acid-coupled limonene bovine...

Cited by 4 publications

References 50 publications

Anticancer effect of terpenes: focus on malignant melanoma

Anticancer effect of terpenes: focus on malignant melanoma

Causal association of polyunsaturated fatty acids with biliary tract diseases: A Mendelian randomization study

Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example

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