Targeting Nrf2/PHKG2 axis to enhance radiosensitivity in NSCLC
Fushi Han,
Shuzhen Chen,
Kangwei Zhang
et al.
Abstract:While ferroptosis shows promise in anti-cancer strategy, the molecular mechanisms behind this process remain poorly understood. Our research aims to highlight the regulation of radiotherapy-induced ferroptosis in non-small cell lung cancer (NSCLC) via the NRF2/PHKG2 axis-mediated mechanism. To identify ferroptosis-associated genes associated with radioresistance in NSCLC, this study employed high-throughput transcriptome sequencing and Lasso risk regression analysis. Clinical samples were analyzed to confirm P… Show more
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