Targeting Nrf2/HO-1 signaling by crocin: Role in attenuation of AA-induced ulcerative colitis in rats

Khodir, Ahmed E.; Said, Eman; Atif, Hoda; El‐Kashef, Hassan A.; Salem, Hatem A.

doi:10.1016/j.biopha.2018.11.133

Cited by 64 publications

(33 citation statements)

References 41 publications

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“…The anti-inflammatory and anti-oxidant characteristics of crocetin and crocin were evaluated in-vivo in various organs including stomach, intestine, liver and kidney [14,15,16,17,18,19]. Saffron components were shown to down-regulate several pro-inflammatory cytokines’ expression.…”

Section: Anti-inflammatory and Anti-carcinogenic Effects Of Saffronmentioning

confidence: 99%

“…The therapeutic impact was mediated primarily via enhancement of colon Nrf2 content by 211% in protective protocol and by 350% in curative protocol and HO-1 signaling by 49% in protective protocol and, 288% in the curative protocol. Enhancement of Nrf2 and HO-1 signaling and down-regulation of caspase-3 activity are believed to underly the observed therapeutic effect [16]. Therefore, crocin could be a candidate for both the prevention of colitis and inflammation-associated colon cancer.…”

Section: Effectiveness Of Saffron In Digestive Diseasesmentioning

confidence: 99%

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Saffron: The Golden Spice with Therapeutic Properties on Digestive Diseases

et al. 2019

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Saffron is a natural compound that has been used for centuries in many parts of the world as a food colorant and additive. It was shown to have the ability to mitigate various disorders through its known anti-inflammatory and anti-oxidant properties. Several studies have shown the effectiveness of saffron in the treatment of various chronic diseases like inflammatory bowel diseases, Alzheimer’s, rheumatoid arthritis as well as common malignancies of the colon, stomach, lung, breast, and skin. Modern day drugs generally have unwanted side effects, which led to the current trend to use naturally occurring products with therapeutic properties. In the present review, the objective is to systematically analyze the wealth of information regarding the potential mechanisms of action and the medical use of saffron, the “golden spice”, especially in digestive diseases. We summarized saffron influence on microbiome, molecular pathways, and inflammation in gastric, colon, liver cancers, and associated inflammations.

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Section: Anti-inflammatory and Anti-carcinogenic Effects Of Saffronmentioning

confidence: 99%

Section: Effectiveness Of Saffron In Digestive Diseasesmentioning

confidence: 99%

Saffron: The Golden Spice with Therapeutic Properties on Digestive Diseases

et al. 2019

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“…It also reduced colon TNF‐α and Ca + 2 contents with down‐regulation of caspase‐3 (CASP3) expression. These results demonstrated that Crocin has antiinflammatory, antioxidant, and antiapoptotic properties resulting in antiulcerogenic and coloprotective effects . Rezaei et al investigated the therapeutic effects of Crocin against chemically induced colitis in mice.…”

Section: Ucmentioning

confidence: 99%

“…These results demonstrated that Crocin has antiinflammatory, antioxidant, and antiapoptotic properties resulting in antiulcerogenic and coloprotective effects. 40 Rezaei et al investigated the therapeutic effects of Crocin against chemically induced colitis in mice. They showed that Crocin treatment reduced colitis symptoms in mice including diarrhea, body weight loss, colon shortening, and rectal bleeding.…”

Section: Ucmentioning

confidence: 99%

Therapeutic effects of Crocin in autoimmune diseases: A review

Korani

Sathyapalan

et al. 2019

BioFactors

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The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple sclerosis. Improved recognition of the mechanisms of ADs has led to the advancement of the management of these diseases. The principal mediators of ADs are inflammatory molecules. The herbal medicines due to their antioxidant and antiinflammatory properties have an important role in the management of ADs. Crocin is the principal chemical component extracted from saffron, which is a medicinal plant. This review focuses on the therapeutic effects of Crocin in various ADs.

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“…Excessive production of ROS can increase membrane permeability and cellular stress, finally resulting in the expansion of facultative anaerobic bacteria, gut barrier dysfunction, and inflammation [14, 15]. Moreover, experimental UC in mice is attenuated by antioxidant interventions [16]. Notably, certain intestinal epithelial cells have been reported to rapidly generate ROS in response to microbial signals [17].…”

Section: Introductionmentioning

confidence: 99%

The Bidirectional Interactions between Resveratrol and Gut Microbiota: An Insight into Oxidative Stress and Inflammatory Bowel Disease Therapy

Chen

Zheng

et al. 2019

BioMed Research International

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Dysbiosis and oxidative stress in the gut have contributed to the progression of intestinal inflammatory bowel disease (IBD). The current study has reported that enteric bacteria mediate redox homeostasis through the regulation of reactive oxygen species (ROS) production. Resveratrol, one of the most abundant polyphenols, with poor oral bioavailability, is considered as a scavenger of ROS and other free radicals. Recent studies have shown that resveratrol effectively enhances the growth of Lactococcus lactis and inhibits the growth of Enterococcus faecalis. (1) In terms of the two-way relationship between gut microbiota and resveratrol, resveratrol modulates gut microbiota; (2) in terms of resveratrol biotransformation by gut microbiota, we speculate that gut microbiota could be a target of resveratrol to maintain gut homeostasis. Here, we reviewed the current researches about the cellular signaling pathways in intestinal epithelial cells triggered by gut microbiota in response to oxidative stress. These results suggest that the modulation of the gut microbiota through resveratrol supplementation appears as a promising potential approach for the therapy of inflammatory bowel disease.

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Targeting Nrf2/HO-1 signaling by crocin: Role in attenuation of AA-induced ulcerative colitis in rats

Cited by 64 publications

References 41 publications

Saffron: The Golden Spice with Therapeutic Properties on Digestive Diseases

Saffron: The Golden Spice with Therapeutic Properties on Digestive Diseases

Therapeutic effects of Crocin in autoimmune diseases: A review

The Bidirectional Interactions between Resveratrol and Gut Microbiota: An Insight into Oxidative Stress and Inflammatory Bowel Disease Therapy

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