Targeting NMDA receptors with an antagonist is a promising therapeutic strategy for treating neurological disorders

Rafe, Md. Rajdoula; Saha, Pranoy; Bello, Stephen Temitayo

doi:10.1016/j.bbr.2024.115173

Behavioural Brain Research

2024

DOI: 10.1016/j.bbr.2024.115173

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Targeting NMDA receptors with an antagonist is a promising therapeutic strategy for treating neurological disorders

Md. Rajdoula Rafe,

Pranoy Saha,

Stephen Temitayo Bello

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2024

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References 117 publications

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Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study

Trainito,

Muscarà,

Gugliandolo

et al. 2024

Cells

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Neurological disorders such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and schizophrenia are associated with altered neuronal excitability, resulting from dysfunctions in the molecular architecture and physiological regulation of ion channels and synaptic transmission. Ion channels and synapses are regarded as suitable therapeutic targets in modern pharmacology. Cannabinoids have received great attention as an original therapeutic approach for their effects on human health due to their ability to modulate the neurotransmitter release through interaction with the endocannabinoid system. In our study, we explored the effect of cannabinol (CBN) through next-generation sequencing analysis of NSC-34 cell physiology. Our findings revealed that CBN strongly influences the ontologies related to ion channels and synapse activity at all doses tested. Specifically, the genes coding for calcium and potassium voltage-gated channel subunits, and the glutamatergic and GABAergic receptors (Cacna1b, Cacna1h, Cacng8, Kcnc3, Kcnd1, Kcnd2, Kcnj4, Grik5, Grik1, Slc17a7, Gabra5), were up-regulated. Conversely, the genes involved into serotoninergic and cholinergic pathways (Htr3a, Htr3b, Htr1b, Chrna3, Chrnb2, Chrnb4), were down-regulated. These findings highlight the influence of CBN in the expression of genes involved into ion influx and synaptic transmission.

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Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study

Trainito,

Muscarà,

Gugliandolo

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

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Targeting NMDA receptors with an antagonist is a promising therapeutic strategy for treating neurological disorders

Cited by 1 publication

References 117 publications

Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study

Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study

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